Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia.

Autor: Lehman A; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Nalintya E; Infectious Disease Institute, Makerere University, Kampala, Uganda., Wele A; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Kirumira P; Infectious Disease Institute, Makerere University, Kampala, Uganda., Naluyima R; Infectious Disease Institute, Makerere University, Kampala, Uganda., Namuli T; Infectious Disease Institute, Makerere University, Kampala, Uganda., Turya Musa F; Infectious Disease Institute, Makerere University, Kampala, Uganda., Skipper CP; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Meya DB; Infectious Disease Institute, Makerere University, Kampala, Uganda., Boulware DR; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Rajasingham R; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2023 Mar 28; Vol. 10 (3), pp. ofad156. Date of Electronic Publication: 2023 Mar 28 (Print Publication: 2023).
DOI: 10.1093/ofid/ofad156
Abstrakt: Among persons with human immunodeficiency virus-associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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