7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice.

Autor:	Rawlings-Mortimer F; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Lazari A; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Tisca C; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Tachrount M; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Martins-Bach AB; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Miller KL; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Lerch JP; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom., Johansen-Berg H; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, Oxford, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in systems neuroscience [Front Syst Neurosci] 2023 Mar 15; Vol. 17, pp. 1134594. Date of Electronic Publication: 2023 Mar 15 (Print Publication: 2023).
DOI:	10.3389/fnsys.2023.1134594
Abstrakt:	Introduction: 7,8-dihydroxyflavone (7,8-DHF) is a low molecular weight compound that can cross the blood brain barrier and has been implicated in numerous functions and behaviours. It is thought to have neuroprotective capability and has been shown to alleviate symptoms in a wide range of diseases. Methods: 7,8-DHF was administered systemically to wildtype mice during Morris water maze training. Long-term spatial memory was assessed 28 days later. Ex-vivo T2-weighted (T2w) imaging was undertaken on a subset of these mice to assess brain-wide changes in volume. Results: We found that systemic 7,8-DHF administration during the training period enhanced spatial memory 28 days later. Volumetric changes were observed in numerous brain regions associated with a broad range of functions including cognition, sensory, and motor processing. Discussion: Our findings give the first whole brain overview of long-term anatomical changes following 7,8-DHF administration providing valuable information for assessing and understanding the widespread effects this drug has been shown to have in behaviour and disease. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Rawlings-Mortimer, Lazari, Tisca, Tachrount, Martins-Bach, Miller, Lerch and Johansen-Berg.)
Databáze:	MEDLINE
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