Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers.

Autor:	Tamrazi A; Division of Vascular and Interventional Radiology, Palo Alto Medical Foundation, Redwood City, CA, United States., Sundaresan S; Department of Clinical Research, Dignity Health, Sequoia Hospital, Redwood City, CA, United States., Gulati A; Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States., Tan FJ; Department of Embryology, Carnegie Institution, Baltimore, MD, United States., Wadhwa V; Division of Interventional Radiology, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, United States., Bartlett BR; Department of Molecular Biosciences and Bioengineering, University of Hawaíi at Mānoa, Honolulu, HI, United States., Diaz LAJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2023 Mar 17; Vol. 13, pp. 916196. Date of Electronic Publication: 2023 Mar 17 (Print Publication: 2023).
DOI:	10.3389/fonc.2023.916196
Abstrakt:	Introduction: Circulating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral veins. Methods: Using an endovascular image-guided approach, we obtained blood samples from peripheral veins and other vascular compartments-including the most proximal venous drainage from solid tumors-from a set of nine oncology patients with various primary and metastatic malignancies. We then interrogated these samples for a panel of oncological biomarkers, including circulating tumor cells (CTCs), exosome-derived microRNAs (miRNAs), circulating tumor DNA (ctDNA) mutations, and certain cancer-related proteins/biochemical markers. Results: We found substantially higher levels of CTCs, certain miRNAs, and specific ctDNA mutations in samples from vascular beds closer to the tumor compared with those from peripheral veins and also noted that some of these signals were altered by treatment procedures. Discussion: Our results indicate that tumor-proximal venous samples are highly enriched for some oncological biomarkers and may allow for more robust molecular analysis than peripheral vein samples. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor ZB declared a shared affiliation with the author FT at the time of review. (Copyright © 2023 Tamrazi, Sundaresan, Gulati, Tan, Wadhwa, Bartlett and Diaz.)
Databáze:	MEDLINE
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