Particle carriers for controlled release of peptides.

Autor: Jiang EY; Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA., Desroches ST; Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA., Mikos AG; Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA. Electronic address: mikos@rice.edu.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Aug; Vol. 360, pp. 953-968. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1016/j.jconrel.2023.03.050
Abstrakt: There has been growing discovery and use of therapeutic peptides in drug delivery and tissue engineering. Peptides are smaller than proteins and can be formulated into drug delivery systems without significant loss of their bioactivity, which remains a concern with proteins. However, the smaller size of peptides has made the controlled release of these bioactive molecules from carriers challenging. Thus, there has been increasing development of carriers to improve the controlled release of peptides by leveraging hydrophobic and electrostatic interactions between the peptide and the carrier. The focus of this review paper is to critically discuss synthetic and natural nanoparticles and microparticles that have been investigated for the controlled delivery of peptides with emphasis on the underlying interactions.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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