CSF dynamics in long-standing overt ventriculomegaly in adults.

Autor:	Pirina A; 1Unit of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy., Jusue-Torres I; 2Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota., Desestret V; 3Department of Neurology D, Neurological Hospital Wertheimer, Lyon University Hospital, Lyon, France.; 4Lyon 1 University, Lyon, France.; 5INSERM U1217/CNRS UMR 5310, Lyon, France., Albini Riccioli L; 6Unit of Neuroradiology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy., Jouanneau E; 4Lyon 1 University, Lyon, France.; 7Department of Skull Base Neurosurgery, Neurological Hospital Wertheimer, Lyon University Hospital, Lyon, France; and.; 8INSERM U1052, CNRS UMR5286, Lyon, France., Palandri G; 1Unit of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy., Manet R; 7Department of Skull Base Neurosurgery, Neurological Hospital Wertheimer, Lyon University Hospital, Lyon, France; and.
Jazyk:	angličtina
Zdroj:	Neurosurgical focus [Neurosurg Focus] 2023 Apr; Vol. 54 (4), pp. E8.
DOI:	10.3171/2023.1.FOCUS22642
Abstrakt:	Objective: Long-standing overt ventriculomegaly in adults (LOVA) is a form of chronic hydrocephalus and its pathophysiology and treatment remain debated. An analysis of CSF dynamics in this condition has rarely been reported. The aim of this study was to analyze hydrodynamic characteristics of patients with suspected LOVA to discuss its pathophysiological mechanisms and the importance of CSF dynamics analysis for diagnosis and treatment of these patients. Methods: This retrospective cohort study, conducted between May 2018 and October 2022, included adult patients aged > 18 years investigated in a department of neurosurgery through a lumbar infusion study for suspicion of LOVA (n = 23). These patients were then compared with a control cohort explored for suspicion of idiopathic normal pressure hydrocephalus (iNPH; n = 30). Clinical symptoms, radiological findings, and hydrodynamic parameters were analyzed. The authors specifically compared two hydrodynamic parameters: resistance to CSF outflow, or Rout, which relies on CSF resorption, and pressure-volume index (PVI), which reflect overall craniospinal compliance. The lumbar infusion study was considered pathological (confirming the diagnosis of chronic hydrocephalus) when at least one of these two parameters was altered. Results: Rout was significantly less frequently increased (cutoff ≥ 12 mm Hg/ml/min) in patients with LOVA (52%) than in those with iNPH (97%; p < 0.001). In contrast, PVI was impaired (cutoff ≤ 25 ml) in both cohorts, i.e., in 61% of patients with LOVA and in 83% of patients with iNPH. Overall, the rate of pathological lumbar infusion study in LOVA (87%) was not statistically different than in iNPH (100%). However, PVI was the only impaired parameter most frequently found in those with LOVA (35%) compared with those with iNPH (3%; p = 0.002). Conclusions: This study suggests that there is a differential CSF dynamics pattern when comparing patients with LOVA versus those with iNPH. A higher proportion of patients with LOVA showed isolated compliance impairment. These findings highlight the utility of CSF dynamics analysis for the evaluation of patients with suspected chronic obstructive hydrocephalus such as LOVA. Future research with larger case series may help define diagnosis and treatment algorithms of chronic obstructive hydrocephalus based on CSF dynamics analysis, in addition to clinical and radiological criteria.
Databáze:	MEDLINE
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