Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19.

Autor: Hosseninia S; Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, 5615780011, Iran., Ghobadi H; Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, 5615780011, Iran., Garjani K; Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Hosseini SAH; Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Aslani MR; Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, 5615780011, Iran. mraslani105@yahoo.com.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. mraslani105@yahoo.com.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2023 Mar 31; Vol. 23 (1), pp. 107. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1186/s12890-023-02397-5
Abstrakt: Background: The role of leukocytes and systemic inflammation indicators in predicting the severity and mortality of inflammatory diseases has been well reported, such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), neutrophil/lymphocyte*platelet ratio (NLPR), derived neutrophil/lymphocyte ratio (dNLR), aggregate index of systemic inflammation (AISI), as well as systemic inflammation response index (SIRI) and systemic inflammation index (SII). The purpose of the present study was to investigate the prognostic role of systemic inflammatory indicators in the mortality of chronic obstructive pulmonary disease (COPD) patients with COVID-19.
Methods: This retrospective study included 169 COPD patients hospitalized with COVID-19. Demographic, clinical, and laboratory data were obtained from the patients' electronic records. The ability of systemic inflammation indeces to distinguish the severity of COVID-19 was determined by receiver operating characteristic (ROC) analysis, and survival probability was determined by the mean of Kaplan-Meier curves, with the endpoint being death.
Results: ROC curves showed that the AUD level was significant for WBC, MLR, SIRI, and AISI. Interestingly, Kaplan-Meier survival curves revealed that survival was lower with higher MLR (HR = 2.022, 95% CI = 1.030 to 3.968, P < 0.05) and AISI (HR = 2.010, 95% CI = 1.048 to 3.855, P < 0.05) values. However, the multivariate Cox regression model showed that only AISI was significantly associated with survival.
Conclusion: AISI in COPD patients with COVID-19 was a reliable predictor of mortality.
(© 2023. The Author(s).)
Databáze: MEDLINE
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