Gene loss during a transition to multicellularity.

Autor: Jiménez-Marín B; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA.; Interdepartmental Genetics Graduate Program, Kansas State University, Manhattan, KS, 66506, USA., Rakijas JB; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA., Tyagi A; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA., Pandey A; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA., Hanschen ER; Los Alamos National Lab, Los Alamos, NM, 87545, USA., Anderson J; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA., Heffel MG; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA.; Interdepartmental Genetics Graduate Program, Kansas State University, Manhattan, KS, 66506, USA., Platt TG; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA., Olson BJSC; Division of Biology, Kansas State University, Manhattan, KS, 66506, USA. bjsco@ksu.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Mar 31; Vol. 13 (1), pp. 5268. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1038/s41598-023-29742-2
Abstrakt: Multicellular evolution is a major transition associated with momentous diversification of multiple lineages and increased developmental complexity. The volvocine algae comprise a valuable system for the study of this transition, as they span from unicellular to undifferentiated and differentiated multicellular morphologies despite their genomes being similar, suggesting multicellular evolution requires few genetic changes to undergo dramatic shifts in developmental complexity. Here, the evolutionary dynamics of six volvocine genomes were examined, where a gradual loss of genes was observed in parallel to the co-option of a few key genes. Protein complexes in the six species exhibited novel interactions, suggesting that gene loss could play a role in evolutionary novelty. This finding was supported by gene network modeling, where gene loss outpaces gene gain in generating novel stable network states. These results suggest gene loss, in addition to gene gain and co-option, may be important for the evolution developmental complexity.
(© 2023. The Author(s).)
Databáze: MEDLINE
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