Eucalcemia during lipopolysaccharide challenge in postpartum dairy cows: II. Calcium dynamics.
Autor: | Chandler TL; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Electronic address: tlc236@cornell.edu., Westhoff TA; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., LaPierre PA; Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853., Frizzarini W; Department of Animal and Dairy Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706., Hernandez LL; Department of Animal and Dairy Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706., Overton TR; Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853., Mann S; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. |
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Jazyk: | angličtina |
Zdroj: | Journal of dairy science [J Dairy Sci] 2023 May; Vol. 106 (5), pp. 3601-3614. Date of Electronic Publication: 2023 Mar 29. |
DOI: | 10.3168/jds.2022-22775 |
Abstrakt: | Hypocalcemia induced by immune activation is a conserved response among mammals. Early postpartum cows will experience decreased circulating Ca concentrations following acute immune activation; however, the cause for decreased Ca concentration is unknown. Our objectives were to (1) describe Ca dynamics following an intravenous (IV) LPS challenge in early postpartum cows, and (2) compare inflammatory-induced changes in Ca dynamics between IV Ca-treated cows and control cows. Cows (n = 14, 8 ± 1 d in milk) were enrolled in a matched-pair randomized controlled design to receive IV Ca (IVCa) in a eucalcemic clamp for 12 h, or 0.9% NaCl (CTRL) following an IV LPS infusion (0.040 or 0.045 µg of LPS/kg of body weight over 1 h). During the 24 h following LPS infusion, circulating concentrations of parathyroid hormone and serotonin were measured, serum and urine samples were collected to calculate urinary fractional excretion of Ca (FECa), and fecal samples were collected to calculate Ca apparent digestibility (ADCa) using amylase-treated and ash-corrected undigested neutral detergent fiber after 240 h (uNDFom (The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).) |
Databáze: | MEDLINE |
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