Regional abnormalities of spontaneous brain activity in migraine: A coordinate-based meta-analysis.

Autor: Wen JJ; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Gao YY; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Li MT; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Hu S; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Zhao MQ; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Su C; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Wang Q; Department of Radiology, Changshu No. 2 People's Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China., Xi HY; School of Western Studies, Heilongjiang University, Harbin, China., Zhan LL; School of Western Studies, Heilongjiang University, Harbin, China., Lv YT; Institute of Brain Science and Department of Psychology, School of Education, Hangzhou Normal University, Hangzhou, China.; Center for Cognition and Brain Disorders, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China., Antwi CO; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Ren J; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China., Jia XZ; School of Teacher Education, Zhejiang Normal University, Jinhua, China.; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2023 Aug; Vol. 101 (8), pp. 1205-1223. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1002/jnr.25191
Abstrakt: Many resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored abnormal regional spontaneous brain activity in migraine. However, these results are inconsistent. To identify the consistent regions with abnormal neural activity, we meta-analyzed these studies. We gathered whole-brain rs-fMRI studies measuring differences in the amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF), or regional homogeneity (ReHo) methods. Then, we performed a voxel-wise meta-analysis to identify consistent abnormal neural activity in migraine by anisotropic effect size seed-based d mapping (AES-SDM). To confirm the AES-SDM meta-analysis results, we conducted two meta-analyses: activation likelihood estimation (ALE) and multi-level kernel density analysis (MKDA). We found that migraine showed increased regional neural activities in the bilateral postcentral gyrus (PoCG), left hippocampus (HIP.L), right pons, left superior frontal gyrus (SFG.L), triangular part of right inferior frontal gyrus (IFGtriang.R), right middle frontal gyrus (MFG.R), and left precentral gyrus (PreCG.L) and decreased regional intrinsic brain activities were exhibited in the right angular gyrus (ANG.R), left superior occipital gyrus (SOG.L), right lingual gyrus (LING.R). Moreover, the meta-analysis of ALE further validated the abnormal neural activities in the PoCG, right pons, ANG.R, and HIP. Meta-regression demonstrated that headache intensity was positively associated with the abnormal activities in the HIP.L, ANG.R, and LING.R. These findings suggest that migraine is associated with abnormal spontaneous brain activities of some pain-related regions, which may contribute to a deeper understanding of the neural mechanism of migraine.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: