| Autor: |
Siebold C; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; email: christian@strubi.ox.ac.uk., Rohatgi R; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, USA; email: rrohatgi@stanford.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Annual review of biochemistry [Annu Rev Biochem] 2023 Jun 20; Vol. 92, pp. 273-298. Date of Electronic Publication: 2023 Mar 31. |
| DOI: |
10.1146/annurev-biochem-052521-040313 |
| Abstrakt: |
Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate tissue development in metazoans. A remarkable feature of HH signaling is the repeated use of cholesterol in steps spanning ligand biogenesis, secretion, dispersal, and reception on target cells. A cholesterol molecule covalently attached to HH ligands is used as a molecular baton by transfer proteins to guide their secretion, spread, and reception. On target cells, a signaling circuit composed of a cholesterol transporter and sensor regulates transmission of HH signals across the plasma membrane to the cytoplasm. The repeated use of cholesterol in signaling supports the view that the HH pathway likely evolved by coopting ancient systems to regulate the abundance or organization of sterol-like lipids in membranes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
