| Autor: |
Pavlova MB; Pavlov Institute of Physiology, St. Petersburg, 199034 Russia.; pavlova@infran.ru., Smagin DA; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia., Kudryavtseva NN; Pavlov Institute of Physiology, St. Petersburg, 199034 Russia.; Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia., Dyuzhnikova NA; Pavlov Institute of Physiology, St. Petersburg, 199034 Russia.; dyuzhikova@infran.ru. |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2023 Mar-Apr; Vol. 57 (2), pp. 373-383. |
| DOI: |
10.31857/S0026898423020192, EDN: EEDPRC |
| Abstrakt: |
Whole-transcriptome data were used to study the changes in expression of genes coding proteins involved in the calcium regulation processes in the hippocampus of male mice with symptoms of depression caused by chronic social defeat stress. Cacna1g, Cacnb3, Camk1g, Camk2d, Camk2n2, Caly, Caln1, S100a16, and Slc24a4 genes were upregulated in the hippocampus of depressed mice compared to a control, while Cacna2d1, Cacng5, Grin2a, and Calm2 were downregulated. The greatest number of significant correlations was observed between the expression level of Calm2, which showed the highest transcriptional activity, and other differentially expressed genes. Calcium signaling in the hippocampus was assumed to be disrupted in mice exposed to chronic social defeat stress. The involvement of Calm2, Camk1g, Camk2d, and Camk2n2 genes in the process is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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