Long-term effectiveness of add-on perampanel in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.

Autor: Matricardi S; Department of Pediatrics, University of Chieti, Chieti, Italy., Cesaroni E; Child Neurology and Psychiatry Unit, Children's Hospital 'G. Salesi', Ospedali Riuniti Ancona, Ancona, Italy., Bonanni P; Epilepsy Unit, IRCCS Eugenio Medea Scientific Institute, Conegliano, Italy., Foschi N; Neurological Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy., D Aniello A; IRCCS Neuromed, Pozzilli, Italy., Di Gennaro G; IRCCS Neuromed, Pozzilli, Italy., Striano P; IRCCS Istituto 'Giannina Gaslini', Genoa, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy., Cappanera S; Child Neurology and Psychiatry Unit, Children's Hospital 'G. Salesi', Ospedali Riuniti Ancona, Ancona, Italy., Siliquini S; Child Neurology and Psychiatry Unit, Children's Hospital 'G. Salesi', Ospedali Riuniti Ancona, Ancona, Italy., Freri E; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Ragona F; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Granata T; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Deleo F; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Villani F; Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Russo A; IRCCS, Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichitaria dell'età Pediatrica, Bologna, Italy., Messana T; IRCCS, Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichitaria dell'età Pediatrica, Bologna, Italy., Siri L; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Bagnasco I; Child Neuropsychiatry To-Sud Martini Hospital, Turin, Italy., Vignoli A; Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, Milan, Italy.; Health Sciences Department, Università degli Studi di Milano, Milan, Italy., Operto FF; Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Dentistry, University of Salerno, Fisciano, Italy., Orsini A; Pediatric Neurology, Pediatric Department, Santa Chiara's University Hospital, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Bonuccelli A; Pediatric Neurology, Pediatric Department, Santa Chiara's University Hospital, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Papa A; Child Neuropsychiatry Unit, University Hospital Maggiore della Carità, Novara, Italy., Peruzzi C; Child and Adolescent Neuropsychiatry Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Liguori C; Department of System Medicine, Policlinico Tor Vergata, Epilepsy Center, University of Rome Tor Vergata, Rome, Italy., Verrotti A; Department of Pediatrics, University of Perugia, Perugia, Italy., Chiarelli F; Department of Pediatrics, University of Chieti, Chieti, Italy., Marini C; Child Neurology and Psychiatry Unit, Children's Hospital 'G. Salesi', Ospedali Riuniti Ancona, Ancona, Italy., Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2023 Jun; Vol. 64 (6), pp. e98-e104. Date of Electronic Publication: 2023 Apr 10.
DOI: 10.1111/epi.17601
Abstrakt: This retrospective study assessed long-term effectiveness of add-on perampanel (PER) in patients with Lennox-Gastaut syndrome (LGS). Outcomes included time to PER failure and time to seizure relapse in responders. PER failure was defined as either discontinuation of PER or initiation of another treatment. Seizure relapse in responders was defined as occurrence of a seizure in seizure-free patients and increase of at least 50% in average monthly seizure frequency for those who were responders. Eighty-seven patients were included. Treatment failure occurred in 52 (59.8%) subjects at a median time of 12 months. Treatment failure was due to lack of efficacy in 27 (52.0%) patients, lack of tolerability in 14 (27.0%), and both reasons in 11 (21.0%). A slower titration was associated with a lower risk of PER failure compared to faster titration schedules, and the occurrence of adverse events increased the risk of treatment failure. Thirty-six patients (41.4%) were responders during a median follow-up of 11 months. Seizure relapse occurred in 13 of 36 (36.1%) patients after a median time of 21 months. The overall rate of seizure responders was 23 of 87 (26.4%) at the end of follow-up. This study provides real-world evidence on the effectiveness of PER as adjunctive treatment in LGS patients.
(© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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