Toxic use of baclofen causing cramps during tapering.

Autor:	Isidor S; Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital., Laursen TL; Medicinsk Afdeling, Regionshospitalet Randers., Bundgaard H; Operation og Intensiv, Regionshospitalet Randers., Sædder EA; Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital., Helgestad OK; Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital.; Hjertemedicinsk Afdeling, Aarhus Universitetshospital.
Jazyk:	dánština
Zdroj:	Ugeskrift for laeger [Ugeskr Laeger] 2023 Mar 27; Vol. 185 (13).
Abstrakt:	The spasmolytic agent baclofen is regarded as having a low dependence potential. This is a case report of a 46-year-old woman with an escalating use of baclofen to four times the highest recommended dose. She was initially admitted to hospital due to decreased consciousness. Later, during tapering, she was readmitted unresponsive with myoclonus. Baclofen was discontinued abruptly during sedation with propofol and remifentanil infusion as well as midazolam in refract doses. Eight days later she was discharged without sequelae.
Databáze:	MEDLINE
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