Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine.

Autor:	Marfia G; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Clinical Pathology Unit, Istituto di Medicina Aerospaziale 'A. Mosso', Aeronautica Militare, Milan, Italy., Guarnaccia L; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Navone SE; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ampollini A; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Balsamo M; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Benelli F; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Gaudino C; Department of Neuroradiology, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy., Garzia E; Istituto di Medicina Aerospaziale 'A. Mosso', Aeronautica Militare, Milan, Italy., Fratocchi C; Clinical Pathology Unit, Istituto di Medicina Aerospaziale 'A. Mosso', Aeronautica Militare, Milan, Italy., Di Murro C; Clinical Pathology Unit, Istituto di Medicina Aerospaziale 'A. Mosso', Aeronautica Militare, Milan, Italy., Ligarotti GK; Istituto di Medicina Aerospaziale 'A. Mosso', Aeronautica Militare, Milan, Italy., Campanella C; Istituto di Medicina Aerospaziale 'Aldo Di Loreto', Aeronautica Militare, Rome, Italy., Landolfi A; Italian Air Force Logistic Command, Rome, Italy., Perelli P; Italian Air Force Logistic Command, Rome, Italy., Locatelli M; Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Medical-Surgical Physiopathology and Transplantation, University of Milan, Milan, Italy., Ciniglio Appiani G; Italian Air Force Logistic Command, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2023 Mar 14; Vol. 14, pp. 1124991. Date of Electronic Publication: 2023 Mar 14 (Print Publication: 2023).
DOI:	10.3389/fphys.2023.1124991
Abstrakt:	The environmental conditions to which astronauts and other military pilots are subjected represent a unique example for understanding and studying the biomechanical events that regulate the functioning of the human body. In particular, microgravity has shown a significant impact on various biological systems, such as the cardiovascular system, immune system, endocrine system, and, last but not least, musculoskeletal system. Among the potential risks of flying, low back pain (LBP) has a high incidence among astronauts and military pilots, and it is often associated with intervertebral disc degeneration events. The mechanisms of degeneration determine the loss of structural and functional integrity and are accompanied by the aberrant production of pro-inflammatory mediators that exacerbate the degenerative environment, contributing to the onset of pain. In the present work, the mechanisms of disc degeneration, the conditions of microgravity, and their association have been discussed in order to identify possible molecular mechanisms underlying disc degeneration and the related clinical manifestations in order to develop a model of prevention to maintain health and performance of air- and space-travelers. The focus on microgravity also allows the development of new proofs of concept with potential therapeutic implications. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Marfia, Guarnaccia, Navone, Ampollini, Balsamo, Benelli, Gaudino, Garzia, Fratocchi, Di Murro, Ligarotti, Campanella, Landolfi, Perelli, Locatelli and Ciniglio Appiani.)
Databáze:	MEDLINE
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