Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8 + β7 integrin + T cells and anti-SARS-CoV-2 IgA response.

Autor: Santa Cruz A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. andrescjoao@med.uminho.pt.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. andrescjoao@med.uminho.pt.; Department of Internal Medicine, Hospital of Braga, Braga, Portugal. andrescjoao@med.uminho.pt.; Clinical Academic Center-Braga, Braga, Portugal. andrescjoao@med.uminho.pt., Mendes-Frias A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Azarias-da-Silva M; INSERM-U1124, Université Paris Cité, Paris, France., André S; INSERM-U1124, Université Paris Cité, Paris, France., Oliveira AI; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Pires O; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Mendes M; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Oliveira B; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Braga M; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Lopes JR; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Domingues R; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Costa R; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Silva LN; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Matos AR; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Ângela C; Department of Internal Medicine, Hospital of Braga, Braga, Portugal., Costa P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Carvalho A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.; Department of Internal Medicine, Hospital of Braga, Braga, Portugal.; Clinical Academic Center-Braga, Braga, Portugal., Capela C; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.; Department of Internal Medicine, Hospital of Braga, Braga, Portugal.; Clinical Academic Center-Braga, Braga, Portugal., Pedrosa J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Castro AG; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Estaquier J; INSERM-U1124, Université Paris Cité, Paris, France. estaquier@yahoo.fr.; CHU de Québec - Université Laval Research Center, Québec City, Québec, Canada. estaquier@yahoo.fr., Silvestre R; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. ricardosilvestre@med.uminho.pt.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. ricardosilvestre@med.uminho.pt.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Mar 30; Vol. 14 (1), pp. 1772. Date of Electronic Publication: 2023 Mar 30.
DOI: 10.1038/s41467-023-37368-1
Abstrakt: Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent individuals with PASC compared to convalescent asymptomatic and uninfected participants, six months following their COVID-19 diagnosis. Both convalescent asymptomatic and PASC cases are characterised by higher CD8 + T cell percentages, however, the proportion of blood CD8 + T cells expressing the mucosal homing receptor β7 is low in PASC patients. CD8 T cells show increased expression of PD-1, perforin and granzyme B in PASC, and the plasma levels of type I and type III (mucosal) interferons are elevated. The humoral response is characterized by higher levels of IgA against the N and S viral proteins, particularly in those individuals who had severe acute disease. Our results also show that consistently elevated levels of IL-6, IL-8/CXCL8 and IP-10/CXCL10 during acute disease increase the risk to develop PASC. In summary, our study indicates that PASC is defined by persisting immunological dysfunction as late as six months following SARS-CoV-2 infection, including alterations in mucosal immune parameters, redistribution of mucosal CD8 + β7Integrin + T cells and IgA, indicative of potential viral persistence and mucosal involvement in the etiopathology of PASC.
(© 2023. The Author(s).)
Databáze: MEDLINE
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