Poly (diglycerol adipate) variants as enhanced nanocarrier replacements in drug delivery applications.

Autor: Jacob PL; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom., Brugnoli B; Dept. of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Del Giudice A; Dept. of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Phan H; Institut de Chimie et des Matériaux Paris-Est, Université de Paris-Est Créteil, CNRS UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France., Chauhan VM; Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Boots Sciences Building, University Park, Nottingham NG7 2RD, United Kingdom., Beckett L; Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Boots Sciences Building, University Park, Nottingham NG7 2RD, United Kingdom., Gillis RB; National Centre for Macromolecular Hydrodynamics, University of Nottingham, Sutton Bonington LE12 5RD, United Kingdom; Biomaterials Group, School of Biosciences, University of Nottingham, Sutton Bonington LE12 5RD, United Kingdom; College of Business, Technology and Engineering, Sheffield Hallam University, Food and Nutrition Group, Sheffield S1 1WB, United Kingdom., Moloney C; School of Medicine, BioDiscovery Institute-3, University Park, Nottingham NG7 2RD, United Kingdom., Cavanagh RJ; School of Medicine, BioDiscovery Institute-3, University Park, Nottingham NG7 2RD, United Kingdom., Krumins E; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom., Reynolds-Green M; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom., Lentz JC; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom., Conte C; Department of Pharmacy, University of Napoli Federico II, Napoli, Italy., Cuzzucoli Crucitti V; Centre for Additive Manufacturing and Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, United Kingdom., Couturaud B; Institut de Chimie et des Matériaux Paris-Est, Université de Paris-Est Créteil, CNRS UMR 7182, 2 rue Henri Dunant, 94320 Thiais, France., Galantini L; Dept. of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Francolini I; Dept. of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy., Howdle SM; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom., Taresco V; School of Chemistry, University Park, Nottingham NG7 2RD, United Kingdom. Electronic address: vincenzo.taresco@nottingham.ac.uk.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2023 Jul; Vol. 641, pp. 1043-1057. Date of Electronic Publication: 2023 Mar 22.
DOI: 10.1016/j.jcis.2023.03.124
Abstrakt: Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and a functionalisable pendant group. Despite showing these advantages over commercial alkyl polyesters, PGA suffers from a series of key drawbacks caused by poor amphiphilic balance. This leads to weak drug-polymer interactions and subsequent low drug-loading in NPs, as well as low NPs stability. To overcome this, in the present work, we applied a more significant variation of the polyester backbone while maintaining mild and sustainable polymerisation conditions. We have investigated the effect of the variation of both hydrophilic and hydrophobic segments upon physical properties and drug interactions as well as self-assembly and NPs stability. For the first time we have replaced glycerol with the more hydrophilic diglycerol, as well as adjusting the final amphiphilic balance of the polyester repetitive units by incorporating the more hydrophobic 1,6-n-hexanediol (Hex). The properties of the novel poly(diglycerol adipate) (PDGA) variants have been compared against known polyglycerol-based polyesters. Interestingly, while the bare PDGA showed improved water solubility and diminished self-assembling ability, the Hex variation demonstrated enhanced features as a nanocarrier. In this regard, PDGAHex NPs were tested for their stability in different environments and for their ability to encode enhanced drug loading. Moreover, the novel materials have shown good biocompatibility in both in vitro and in vivo (whole organism) experiments.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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