Ovarian stimulation does not induce thyrotropin receptor autoantibodies in women with thyroid autoimmunity.

Autor:	Poppe KG; Endocrine Unit, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute 322, 1000 Brussels, Belgium., Frommer L; Molecular Thyroid Lab, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Centre, Mainz 55101, Germany., Hatun B; Molecular Thyroid Lab, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Centre, Mainz 55101, Germany., Autin C; Department of Gynaecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute 322, 1000 Brussels, Belgium., Wolff F; Department of Clinical Chemistry, LHUB-ULB, Université Libre de Bruxelles (ULB), Rue Haute 322, 1000 Brussels, Belgium., Kahaly GJ; Molecular Thyroid Lab, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Centre, Mainz 55101, Germany.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2023 Apr 05; Vol. 188 (4), pp. K24-K28.
DOI:	10.1093/ejendo/lvad045
Abstrakt:	Women of subfertile couples with thyroid autoimmunity (TAI) have an increased risk of miscarriage when pregnant after an assisted reproductive technology (ART) treatment. This might amongst others be due to the presence of thyrotropin receptor antibodies (TSH-R-Ab) that can impede the development of the corpus luteum. TSH-R-Ab can be present in women with TAI and/or be induced by the ovarian stimulation procedure (OS) that is performed to initiate the ART. In this prospective pilot study, we determined the presence of both binding and functional TSH-R-Ab (stimulating or blocking) with five different assays before and after OS in ten women (eleven cycles) with TAI of subfertile couples and in one woman without TAI. Mean (SD) age was 38.8 (±3.2) years, median (range) cumulative OS dose 1413 (613-2925) IU/L. Median baseline serum levels of thyrotropin, free thyroxine, and thyro-peroxidase antibodies were 2.33 (2.23-2.61) mIU/L, 16.8 (14.4-18.5) pmol/L and 152 (86-326) kIU/L, respectively. Oestradiol levels increased during OS from 40 (26-56) ng/L to 963 (383-5095) ng/L; P < .01. TSH-R-Ab measurements in all subject samples were below the cut-off of the corresponding immunoassay and four bioassays before or after OS. Competing Interests: Conflicts of interest: K.G.P. received lecture fees from the IBSA Institut Biochimique SA, the Berlin-Chemie AG, and the Merck Company between 2016 and 2022. G.J.K. consults for and the JGU Medical Centre receives research-associated funding from Quidelortho, United States. (© The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu