Neocortical and medial temporal seizures have distinct impacts on brain responsiveness.

Autor: Russo S; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy.; Allen Institute for Brain Science, Seattle, Washington, USA.; Department of Philosophy 'Piero Martinetti', University of Milan, Milan, Italy., Mikulan E; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., Zauli FM; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy.; Department of Philosophy 'Piero Martinetti', University of Milan, Milan, Italy.; 'Claudio Munari' Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy., Sartori I; 'Claudio Munari' Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy., Solbiati M; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., Furregoni G; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., Porro M; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy.; Department of Philosophy 'Piero Martinetti', University of Milan, Milan, Italy., Revay M; 'Claudio Munari' Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy., Rosanova M; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., David O; Inserm, INS, Institut de Neurosciences des Systèmes, Aix Marseille Université, Marseille, France., Massimini M; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy.; Azrieli Program in Brain, Mind and Consciousness, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.; IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy., Tassi L; 'Claudio Munari' Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy., Pigorini A; 'Claudio Munari' Epilepsy Surgery Centre, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milan, Italy.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2023 Jun; Vol. 64 (6), pp. e118-e126. Date of Electronic Publication: 2023 Apr 14.
DOI: 10.1111/epi.17580
Abstrakt: Focal epileptic seizures are characterized by abnormal neuronal discharges that can spread to other cortical areas and interfere with brain activity, thereby altering the patient's experience and behavior. The origin of these pathological neuronal discharges encompasses various mechanisms that converge toward similar clinical manifestations. Recent studies have suggested that medial temporal lobe (MTL) and neocortical (NC) seizures are often underpinned by two characteristic onset patterns, which, respectively, affect and spare synaptic transmission in cortical slices. However, these synaptic alterations and their effects have never been confirmed or studied in intact human brains. To fill this gap, we here evaluate whether responsiveness of MTL and NC are differentially affected by focal seizures, using a unique data set of cortico-cortical evoked potentials (CCEPs) collected during seizures triggered by single-pulse electrical stimulation (SPES). We find that responsiveness is abruptly reduced by the onset of MTL seizures, despite increased spontaneous activity, whereas it is preserved in the case of NC seizures. The present results provide an extreme example of dissociation between responsiveness and activity and show that brain networks are diversely affected by the onset of MTL and NC seizures, thus extending at the whole brain level the evidence of synaptic alteration found in vitro.
(© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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