Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life.

Autor: Nishi K; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan.; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yoshimura C; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan., Morita K; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan., Ishikawa R; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan., Toyokura E; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan., Nagasaki T; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsumoto H; Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan., Nishizaka Y; Department of Respiratory Medicine, Osaka Red Cross Hospital, Osaka, Japan.
Jazyk: angličtina
Zdroj: The World Allergy Organization journal [World Allergy Organ J] 2023 Mar 20; Vol. 16 (3), pp. 100756. Date of Electronic Publication: 2023 Mar 20 (Print Publication: 2023).
DOI: 10.1016/j.waojou.2023.100756
Abstrakt: Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores ( P  = 0.003), maintenance oral corticosteroid doses ( P  = 0.027), and exacerbation frequency ( P  = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change ( P  = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight ( P  = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.
(© 2023 The Author(s).)
Databáze: MEDLINE
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