Updates in the Management of Hyperglycemic Crisis.

Autor:	Aldhaeefi M; Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Pharmaceutical Care Services, King Abdulaziz Medical City, Riyadh, Saudi Arabia., Aldardeer NF; Department of Pharmacy Services, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia., Alkhani N; Department of Pharmacy Services, King Fahad Medical City, Riyadh, Saudi Arabia., Alqarni SM; Doctor of Pharmacy Program, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Alhammad AM; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmacy Services, King Saud University Medical City, Riyadh, Saudi Arabia., Alshaya AI; Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Pharmaceutical Care Services, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Frontiers in clinical diabetes and healthcare [Front Clin Diabetes Healthc] 2022 Feb 09; Vol. 2, pp. 820728. Date of Electronic Publication: 2022 Feb 09 (Print Publication: 2021).
DOI:	10.3389/fcdhc.2021.820728
Abstrakt:	Diabetes mellitus (DM) affects the metabolism of primary macronutrients such as proteins, fats, and carbohydrates. Due to the high prevalence of DM, emergency admissions for hyperglycemic crisis, diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are fairly common and represent very challenging clinical management in practice. DKA and HHS are associated with high mortality rates if left not treated. The mortality rate for patients with DKA is < 1% and ~ 15% for HHS. DKA and HHS have similar pathophysiology with some few differences. HHS pathophysiology is not fully understood. However, an absolute or relative effective insulin concentration reduction and increased in catecholamines, cortisol, glucagon, and growth hormones represent the mainstay behind DKA pathophysiology. Reviewing the patient's history to identify and modify any modifiable precipitating factors is crucial to prevent future events. The aim of this review article is to provide a review of the DKA, and HHS management based on the most recently published evidence and to provide suggested management pathway of DKA of HHS management in practice. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Aldhaeefi, Aldardeer, Alkhani, Alqarni, Alhammad and Alshaya.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu