Mitigating antimicrobial resistance (AMR) using implementation research: a development funder's approach.

Autor:	Khurana MP; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark.; Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Essack S; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark.; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Zoubiane G; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark., Sreenivasan N; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark., Cordoba GC; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark., Westwood E; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark., Dalsgaard A; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark.; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark., Mdegela RH; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania., Mpundu M; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark.; ReAct Africa, Lusaka, Zambia., Scotini R; World Diabetes Foundation, Bagsværd 2880, Denmark., Matondo AB; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania., Mzula A; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania., Chanishvili N; George Eliava Institute of Bacteriophage Microbiology and Virology, Gotua Street 3, Tbilisi 0160, Georgia., Gogebashvili D; LTD Invet Group, 84a, Vakhushti Bagrationi Street, Tbilisi 0154, Georgia., Beruashvili M; Ministry of Environmental Protection and Agriculture of Georgia, Marshal Gelovani 6, Tbilisi 0159, Georgia.; The Faculty of Veterinary Medicine, European University, Tbilisi, Georgia., Tsereteli M; Department of Communicable Diseases, National Center for Disease Control and Public Health, Kakheti Highway 99, Tbilisi 0198, Georgia., Sooronbaev T; National Center of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Togolok Moldo Str, 3, Bishkek 720040, Kyrgyzstan., Kjærgaard J; Department of Children and Adolescents, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark., Bloch J; Department of Children and Adolescents, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark., Isaeva E; National Center of Maternity and Childhood Care, Akhunbaev Str, 190, Bishkek 720038, Kyrgyzstan.; Department of Public Health, The Research Unit for General Practice and Section of General Practice, University of Copenhagen, Øster Farimagsgade 5, Copenhagen 1354, Denmark., Mainda G; Department of Veterinary Services, Ministry of Fisheries and Livestock, PO Box 50060, Lusaka, Zambia., Muuka G; Department of Veterinary Services, Ministry of Fisheries and Livestock, PO Box 50060, Lusaka, Zambia., Mudenda NB; School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia., Goma FY; Department of Veterinary Services, Ministry of Fisheries and Livestock, PO Box 50060, Lusaka, Zambia., Chu DH; Department of Animal Health, Ministry of Agriculture and Rural Development, Ha Noi 115-19, Viet Nam., Chanda D; University Teaching Hospital, Box 17, UTH Post Office, Nationalist Rd., Lusaka, Zambia.; Ministry of Health, Ndeke House, Haile Selassie Avenue, PO Box 30205, Lusaka, Zambia., Chirwa U; University Teaching Hospital, Box 17, UTH Post Office, Nationalist Rd., Lusaka, Zambia.; Ministry of Health, Ndeke House, Haile Selassie Avenue, PO Box 30205, Lusaka, Zambia., Yamba K; School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.; University Teaching Hospital, Box 17, UTH Post Office, Nationalist Rd., Lusaka, Zambia., Kapolowe K; University Teaching Hospital, Box 17, UTH Post Office, Nationalist Rd., Lusaka, Zambia., Fwoloshi S; University Teaching Hospital, Box 17, UTH Post Office, Nationalist Rd., Lusaka, Zambia.; Ministry of Health, Ndeke House, Haile Selassie Avenue, PO Box 30205, Lusaka, Zambia., Mwenge L; Zambart, Health Economics Unit, Ridgeway, Zambia., Skov R; ICARS, International Centre for Antimicrobial Resistance Solutions, Ørestads Boulevard 5, Copenhagen 2300, Denmark.
Jazyk:	angličtina
Zdroj:	JAC-antimicrobial resistance [JAC Antimicrob Resist] 2023 Mar 27; Vol. 5 (2), pp. dlad031. Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).
DOI:	10.1093/jacamr/dlad031
Abstrakt:	Despite the escalating burden of antimicrobial resistance (AMR), the global response has not sufficiently matched the scale and scope of the issue, especially in low- and middle-income countries (LMICs). While many countries have adopted national action plans to combat AMR, their implementation has lagged due to resource constraints, dysfunctional multisectoral coordination mechanisms and, importantly, an under-recognized lack of technical capacity to adapt evidence-based AMR mitigation interventions to local contexts. AMR interventions should be tailored, context-specific, cost-effective and sustainable. The implementation and subsequent scale-up of these interventions require multidisciplinary intervention-implementation research (IIR). IIR involves both quantitative and qualitative approaches, occurs across a three-phase continuum (proof of concept, proof of implementation and informing scale-up), and across four context domains (inner setting, outer setting, stakeholders and the implementation process). We describe the theoretical underpinnings of implementation research (IR), its various components, and how to construct different IR strategies to facilitate sustainable uptake of AMR interventions. Additionally, we provide real-world examples of AMR strategies and interventions to demonstrate these principles in practice. IR provides a practical framework to implement evidence-based and sustainable AMR mitigation interventions. (© The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu