PVC containing silver nanoparticles with antimicrobial properties effective against SARS-CoV-2.

Autor: da Silva DJ; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil., Gramcianinov GB; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil., Jorge PZ; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil., Malaquias VB; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Mori AA; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Hirata MH; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Lopes SAM; BRGoods Indústria e Comércio de Produtos Hospitalares, Indaiatuba, SP, Brazil., Bueno LA; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil., Champeau M; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil., Carastan DJ; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, SP, Brazil.
Jazyk: angličtina
Zdroj: Frontiers in chemistry [Front Chem] 2023 Mar 13; Vol. 11, pp. 1083399. Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023).
DOI: 10.3389/fchem.2023.1083399
Abstrakt: Poly (vinyl chloride) (PVC) is commonly used to manufacture biomedical devices and hospital components, but it does not present antimicrobial activity enough to prevent biofouling. With the emergence of new microorganisms and viruses, such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that was responsible for the global pandemic caused by Coronavirus Disease 2019 (COVID-19), it is evident the importance of the development of self-disinfectant PVC for hospital environments and medical clinics where infected people remain for a long time. In this contribution, PVC nanocomposites with silver nanoparticles (AgNPs) were prepared in the molten state. AgNPs are well-known as antimicrobial agents suitable for designing antimicrobial polymer nanocomposites. Adding 0.1 to 0.5 wt% AgNPs significantly reduced Young's modulus and ultimate tensile strength of PVC due to the emergence of microstructural defects in the PVC/AgNP nanocomposites, but the impact strength did not change significantly. Furthermore, nanocomposites have a higher yellowness index (YI) and lower optical bandgap values than PVC. The PVC/AgNP nanocomposites present virucidal activity against SARS-CoV-2 (B.1.1.28 strain) within 48 h when the AgNP content is at least 0.3 wt%, suitable for manufacturing furniture and hospital equipment with self-disinfectant capacity to avoid secondary routes of COVID-19 contagion.
Competing Interests: SL was employed by BRGoods Indústria e Comércio de Produtos Hospitalares. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that all funders were not involved in the collection, analysis, interpretation of the study design and data, or the writing or submission of the article for publication decisions.
(Copyright © 2023 da Silva, Gramcianinov, Jorge, Malaquias, Mori, Hirata, Lopes, Bueno, Champeau and Carastan.)
Databáze: MEDLINE