Hardwired to attack: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

Autor:	Lischinsky JE; Neuroscience Institute, New York University School of Medicine, New York, NY, USA., Yin L; Neuroscience Institute, New York University School of Medicine, New York, NY, USA., Shi C; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Hunter College, New York, NY, USA., Prakash N; Center for Neuroscience Research, Children's National Hospital, Washington, DC, United States., Burke J; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Shekaran G; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Grba M; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Corbin JG; Center for Neuroscience Research, Children's National Hospital, Washington, DC, United States., Lin D; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA.; Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 17. Date of Electronic Publication: 2023 Mar 17.
DOI:	10.1101/2023.03.16.532692
Abstrakt:	Social behaviors are innate and supported by dedicated neural circuits, but it remains unclear whether these circuits are developmentally hardwired or established through social experience. Here, we revealed distinct response patterns and functions in social behavior of medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages. MeA cells in male mice that express the transcription factor Foxp2 (MeA Foxp2 ) are specialized for processing male conspecific cues even before puberty and are essential for adult inter-male aggression. In contrast, MeA cells derived from the Dbx1 -lineage (MeA Dbx1 ) respond broadly to social cues and are non-essential for male aggression. Furthermore, MeA Foxp2 and MeA Dbx1 cells show differential anatomical and functional connectivity. Altogether, our results support a developmentally hardwired aggression circuit at the level of the MeA and we propose a lineage-based circuit organization by which a cell's embryonic transcription factor profile determines its social information representation and behavior relevance during adulthood. Competing Interests: Declaration of Interests The authors declare no competing interests.
Databáze:	MEDLINE
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