Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil.

Autor: Peixoto LFAA; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil., Abtibol-Bernardino MR; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Department of Maternal and Child Health, Medical School, Federal University of Amazonas, Manaus 69020-160, Brazil., Guerra CVC; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil., de Oliveira GA; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Chaves BCS; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil., de Souza Rodrigues C; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil., de Andrade ABCA; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil., de Fátima Redivo E; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil., Fernandes SSA; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Otani RH; School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil., da Silva Neto AV; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., da Silva Balieiro AA; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil., Cabral CRB; Department of Maternal and Child Health, Medical School, Federal University of Amazonas, Manaus 69020-160, Brazil.; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil., Baia-da-Silva D; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Department of Maternal and Child Health, Medical School, Federal University of Amazonas, Manaus 69020-160, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil.; School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil.; Faculty of Pharmacy, University Nilton Lins, Manaus 69058-030, Brazil., Castilho MDC; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil., Bôtto-Menezes CH; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil., Alecrim MDGC; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Medical Course Coordination at Manaus Metropolitan College/FAMETRO, Manaus 69050-000, Brazil., Leal MDC; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil.; Oswaldo Cruz Institute, FIOCRUZ Rio de Janeiro, Rio de Janeiro 21040-360, Brazil., Benzecry SG; School of Health Sciences, University of Amazonas State, Manaus 69065-001, Brazil., Martinez-Espinosa FE; Postgraduate Program in Tropical Medicine (PPGMT), State University of Amazonas (UEA) in Partnership with the Tropical Medicine Foundation Dr. Heitor Vieira Dourado (FMT-HVD), Manaus 69040-000, Brazil.; Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Leônidas & Maria Deane Institute, ILMD/FIOCRUZ Amazonia, Manaus 69057-070, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2023 Mar 01; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 01.
DOI: 10.3390/v15030662
Abstrakt: The high incidence of Zika virus (ZIKV) infection in the period of 2015-2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of children exposed to ZIKV during pregnancy and followed up in a tertiary unit, a reference for tropical and infectious diseases in the Amazon. Seventy-one children born between March 2016 and June 2018 were monitored for anthropometric indices: z-score for body mass index (BMI/A); weight (W/A); height (H/A) and head circumference (HC/A); and growth velocity. The mean age at the last assessment was 21.1 months (SD ± 8.93). Four children had congenital microcephaly and severe neurological impairment. The other 67 were non-microcephalic children (60 normocephalic and 7 macrocephalic); of these; 24.2% (16 children) had neurological alterations, and 28.8% (19 children) had altered neuropsychomotor development. Seventeen (24.2%) children had inadequate GV (low growth velocity). The frequencies of low growth among microcephalic and non-microcephalic patients are 25% (1 of 4 children) and 23.9% (16 of 67 children); respectively. Most children had normal BMI/A values during follow-up. Microcephalic patients showed low H/A and HC/A throughout the follow-up, with a significant reduction in the HC/A z-score. Non-microcephalic individuals are within the regular ranges for H/A; HC/A; and W/A, except for the H/A score for boys. This study showed low growth velocity in children with and without microcephaly, highlighting the need for continuous evaluation of all children born to mothers exposed to ZIKV during pregnancy.
Databáze: MEDLINE
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