| Autor: |
Bird N; Department of Genetics, Evolution and Environment, University College London Genetics Institute (UGI), University College London, London, UK., Ormond L; Department of Genetics, Evolution and Environment, University College London Genetics Institute (UGI), University College London, London, UK., Awah P; Faculty of Arts, Letters and Social Sciences, University of Yaoundé I, Yaoundé, Cameroon., Caldwell EF; The Library, Lancaster University, Lancaster, UK., Connell B; Linguistics and Language Studies Program, York University, Toronto, Ontario, Canada., Elamin M; University Hospital of Derby, Derby, UK., Fadlelmola FM; Kush Centre for Genomics and Biomedical Informatics, Biotechnology Perspectives Organisation, Khartoum, Sudan., Matthew Fomine FL; Department of History and African Civilisations, University of Buea, Buea, Cameroon., López S; Wellcome Trust, London, UK., MacEachern S; Division of Social Science, Duke Kunshan University, Kunshan, China., Moñino Y; LLACAN, CNRS, Paris, France., Morris S; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Näsänen-Gilmore P; Tampere Centre for Child, Adolescent and Maternal Health Research: Global Health Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department for Health Promotion, Finnish Institute for Health and Welfare, Helsinki, Finland., Nketsia V NK; Essikado Traditional Council, Essikado, Ghana., Veeramah K; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA., Weale ME; Genomics PLC, Oxford, UK., Zeitlyn D; School of Anthropology and Museum Ethnography, University of Oxford, Oxford, UK., Thomas MG; Department of Genetics, Evolution and Environment, University College London Genetics Institute (UGI), University College London, London, UK., Bradman N; Henry Stewart Group, London, UK., Hellenthal G; Department of Genetics, Evolution and Environment, University College London Genetics Institute (UGI), University College London, London, UK. |
| Abstrakt: |
Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language-speaking peoples. |
