MAIT cells activate dendritic cells to promote T FH cell differentiation and induce humoral immunity.

Autor:	Pankhurst TE; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Buick KH; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Lange JL; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Marshall AJ; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Button KR; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Palmer OR; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Farrand KJ; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Montgomerie I; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Bird TW; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Mason NC; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Kuang J; Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand., Compton BJ; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Comoletti D; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Salio M; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Cerundolo V; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Quiñones-Mateu ME; Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand., Painter GF; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Hermans IF; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Connor LM; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand; Malaghan Institute of Medical Research, Wellington 6242, New Zealand. Electronic address: lisa.connor@vuw.ac.nz.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Apr 25; Vol. 42 (4), pp. 112310. Date of Electronic Publication: 2023 Mar 28.
DOI:	10.1016/j.celrep.2023.112310
Abstrakt:	Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered parenterally and are largely ineffective at inducing mucosal immunity. The development of safe and effective mucosal vaccines has been hampered by the lack of a suitable mucosal adjuvant. In this study we explore a class of adjuvant that harnesses mucosal-associated invariant T (MAIT) cells. We show evidence that intranasal immunization of MAIT cell agonists co-administered with protein, including the spike receptor binding domain from SARS-CoV-2 virus and hemagglutinin from influenza virus, induce protective humoral immunity and immunoglobulin A production. MAIT cell adjuvant activity is mediated by CD40L-dependent activation of dendritic cells and subsequent priming of T follicular helper cells. In summary, we show that MAIT cells are promising vaccine targets that can be utilized as cellular adjuvants in mucosal vaccines. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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