Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients.

Autor: Zendelovska D; 1University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, RN Macedonia., Atanasovska E; 1University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, RN Macedonia., Spasovska K; 2University Clinic for Infectious Diseases and Febrile Conditions, Skopje, RN Macedonia., Kirijas M; 3University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Immunobiology and human genetics, Skopje, RN Macedonia., Kapsarov K; 2University Clinic for Infectious Diseases and Febrile Conditions, Skopje, RN Macedonia., Jakimovski D; 2University Clinic for Infectious Diseases and Febrile Conditions, Skopje, RN Macedonia., Petrushevska M; 1University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, RN Macedonia.
Jazyk: angličtina
Zdroj: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) [Pril (Makedon Akad Nauk Umet Odd Med Nauki)] 2023 Mar 29; Vol. 44 (1), pp. 7-16. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
DOI: 10.2478/prilozi-2023-0002
Abstrakt: Background : COVID-19 is a disease in several stages starting with virus replication to dysregulation in immune system response, organ failure and recovery/death. Our aim was to determine the effect of Ganoderma lucidum, lycopene, sulforaphane, royal jelly and resveratrol extract on markers of oxidative stress, inflammation, routine laboratory analyses and duration of symptoms in COVID-19 patients. Methods : The oxidative stress parameters and interleukines 6 and 8 (IL-6, IL-8), tumor necrosis factor alpha (TNF-α) were determined in order to estimate the antioxidant and the anti-inflammatory effect of the product using a spectrophotometric and a magnetic bead-based multiplex assay in serum of 30 patients with mild form of COVID-19. Results : Statistically significant differences were obtained for all investigated parameters between the treated patients and the control group. Moreover, significant differences were observed for leukocytes, neutrophil to leukocyte ratio and iron. The average duration of the symptoms was 9.4±0.487 days versus 13.1±0.483 days in the treatment and the control group, respectively (p=0.0003). Conclusion : Our results demonstrated the promising effect of Ge132+Natural TM on reducing the oxidative stress and the IL-6, IL-8 and TNF-α levels, and symptoms duration in COVID-19 patients. The evidence presented herein suggest that the combination of Ganoderma lucidum extract, lycopene, sulforaphane, royal jelly and resveratrol could be used as a potent an adjuvant therapy in diseases accompanied by increased oxidative stress and inflammation.
(© 2023 Dragica Zendelovska et al., published by Sciendo.)
Databáze: MEDLINE
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