Analysis of Characteristics and Risk Factors of Patients with Single Gastric Cancer and Synchronous Multiple Gastric Cancer among 14,603 Patients.

Autor: Song DH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim N; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea., Jo HH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea., Kim S; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Choi Y; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Oh HJ; Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea., Lee HS; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea., Yoon H; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Shin CM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Park YS; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee DH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea., Kang SH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Park YS; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Ahn SH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Suh YS; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea., Park DJ; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea., Kim HH; Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea., Kim JW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim JW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee KW; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea., Chang W; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea., Park JH; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea., Lee YJ; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea., Lee KH; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea., Kim YH; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea., Ahn S; Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea., Surh YJ; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea.
Jazyk: angličtina
Zdroj: Gut and liver [Gut Liver] 2024 Mar 15; Vol. 18 (2), pp. 231-244. Date of Electronic Publication: 2023 Mar 29.
DOI: 10.5009/gnl220491
Abstrakt: Background/aims: Synchronous multiple gastric cancer (SMGC) accounts for approximately 6% to 14% of gastric cancer (GC) cases. This study aimed to identify risk factors for SMGC.
Methods: A total of 14,603 patients diagnosed with GC were prospectively enrolled. Data including age, sex, body mass index, smoking, alcohol consumption, family history, p53 expression, microsatellite instability, cancer classification, lymph node metastasis, and treatment were collected. Risk factors were analyzed using logistic regression analysis between a single GC and SMGC.
Results: The incidence of SMGC was 4.04%, and that of early GC (EGC) and advanced GC (AGC) was 5.43% and 3.11%, respectively. Patients with SMGC were older (65.33 years vs 61.75 years, p<0.001) and more likely to be male. Lymph node metastasis was found in 27% of patients with SMGC and 32% of patients with single GC. Multivariate analysis showed that SMGC was associated with sex (male odds ratio [OR], 1.669; 95% confidence interval [CI], 1.223 to 2.278; p=0.001), age (≥65 years OR, 1.532; 95% CI, 1.169 to 2.008; p=0.002), and EGC (OR, 1.929; 95% CI, 1.432 to 2.600; p<0.001). Survival rates were affected by Lauren classification, sex, tumor size, cancer type, distant metastasis, and venous invasion but were not related to the number of GCs. However, the survival rate of AGC with SMGC was very high.
Conclusions: SMGC had unique characteristics such as male sex, older age, and EGC, and the survival rate of AGC, in which the intestinal type was much more frequent, was very good (Trial registration number: NCT04973631).
Databáze: MEDLINE
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