| Autor: |
De Piano R; Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, 84084 Fisciano, Italy., Caccavo D; Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, 84084 Fisciano, Italy.; Eng4Life srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy.; EST srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy., Lamberti G; Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, 84084 Fisciano, Italy.; Eng4Life srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy.; EST srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy., Remaut K; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., Seynaeve H; Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., Barba AA; Eng4Life srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy.; EST srl, University Spin-Off, Via Circumvallazione n.39, 83100 Avellino, Italy.; Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, 84084 Fisciano, Italy. |
| Abstrakt: |
The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies. |
