| Autor: |
Santo BLSDE; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Santana LF; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Kato Junior WH; Graduate of Pharmaceutical Sciences, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Araújo FO; Graduate of Electrical Engineering, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Tatara MB; Health Science Research Laboratory, Federal University of Grande Dourados, Dourados 79804-970, Brazil., Croda J; School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.; Oswaldo Cruz Foundation, Campo Grande 79074-460, Brazil., Bogo D; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Freitas KC; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Guimarães RCA; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Hiane PA; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Pott A; Laboratory of Botany, Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Filiú WFO; Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., Faria BB; Diagnostic Medicine Laboratory-Scapulatempo, Campo Grande 79002-17, Brazil., Figueiredo PO; Laboratory of Pronabio (Bioactive Natural Products), Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil., do Nascimento VA; Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Ayres FL; Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil., Bastos PRHO; Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil. |
| Abstrakt: |
The study of medicinal plants, such as the genus Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of G. gardneriana at doses of 200 or 400 mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of 200 mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). In addition, hepatic steatosis and microvesicular steatosis were indicated. It was revealed that, under the experimental conditions in the study, G. gardneriana did not prevent weight gain or comorbidities; that is, a different behavior was obtained from that described in the literature with regard to the medicinal potential of the Garcinia species, which is probably related to the phytochemical properties. |
