Multicentre Surveillance of Candida Species from Blood Cultures during the SARS-CoV-2 Pandemic in Southern Europe (CANCoVEU Project).

Autor: Boattini M; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy.; Department of Public Health and Paediatrics, University of Torino, 10124 Turin, Italy., Pinto MF; Serviço de Patologia Clínica, Laboratório de Microbiologia, Centro Hospitalar Universitário de Lisboa Central, 1169-45 Lisbon, Portugal., Christaki E; Department of Internal Medicine and Infectious Diseases Unit, University Hospital of Ioannina, 455 00 Ioannina, Greece., Fasciana T; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy., Falces-Romero I; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain.; CIBERINFECT, Instituto de Salud Carlos III, 28046 Madrid, Spain., Tofarides A; Department of Internal Medicine, Nicosia General Hospital, Nicosia 2029, Cyprus., Bianco G; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy., Cendejas-Bueno E; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain., Tricoli MR; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy., Tsiolakkis G; Department of Internal Medicine, Nicosia General Hospital, Nicosia 2029, Cyprus., García-Rodríguez J; Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain., Matzaras R; Department of Internal Medicine and Infectious Diseases Unit, University Hospital of Ioannina, 455 00 Ioannina, Greece., Comini S; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy.; Department of Public Health and Paediatrics, University of Torino, 10124 Turin, Italy., Giammanco A; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy., Kasapi D; Department of Internal Medicine, Nicosia General Hospital, Nicosia 2029, Cyprus., Almeida A; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, 1169-050 Lisbon, Portugal.; NOVA Medical School, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056 Lisbon, Portugal., Gartzonika K; Department of Microbiology, Faculty of Medicine, University of Ioannina, 451 10 Ioannina, Greece., Cavallo R; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy.; Department of Public Health and Paediatrics, University of Torino, 10124 Turin, Italy., Costa C; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy.; Department of Public Health and Paediatrics, University of Torino, 10124 Turin, Italy.
Jazyk: angličtina
Zdroj: Microorganisms [Microorganisms] 2023 Feb 23; Vol. 11 (3). Date of Electronic Publication: 2023 Feb 23.
DOI: 10.3390/microorganisms11030560
Abstrakt: Introduction : Surveillance of Candida species isolates from blood cultures (BCs) in Europe is considered fragmented, unable to allow the definition of targets of antifungal stewardship recommendations especially during the SARS-CoV-2 pandemic. Methods : We performed a multicentric retrospective study including all consecutive BC Candida isolates from six Southern European tertiary hospitals (1st January 2020 to 31st December 2021). Etiology, antifungal susceptibility patterns, and clinical setting were analyzed and compared. Results : C. albicans was the dominant species (45.1%), while C. auris was undetected. Candida species positive BC events increased significantly in COVID-19 ICUs in 2021 but decreased in other ICUs. Resistance to azole increased significantly and remained very high in C. albicans (fluconazole from 0.7% to 4.5%, p = 0.03) and C. parapsilosis complex (fluconazole up to 24.5% and voriconazole up to 8.9%), respectively. Resistance to caspofungin was remarkable in C. tropicalis (10%) and C. krusei (20%), while resistance to at least one echinocandin increased in 2021, especially in C. parapsilosis complex (from 0.8% to 5.1%, p = 0.05). Although no significant differences were observed over the study period, fluconazole and echinocandin resistance increased in COVID-19 ICUs by up to 14% and 5.8%, respectively, but remained undetected in non-intensive COVID-19 wards. Conclusions : Antifungal stewardship activities aimed at monitoring resistance to echinocandin in C. tropicalis and C. krusei , and against the spread of fluconazole resistant C. parapsilosis complex isolates are highly desirable. In COVID-19 patients, antifungal resistance was mostly present when the illness had a critical course.
Databáze: MEDLINE
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