| Autor: |
Zanatta AC; Department of Biochemistry and Organic Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.; Institute of Biosciences, São Paulo State University (UNESP), São Vicente 11380-972, SP, Brazil.; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK., Vieira NC; Department of Biochemistry and Organic Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil., Dantas-Medeiros R; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Vilegas W; Institute of Biosciences, São Paulo State University (UNESP), São Vicente 11380-972, SP, Brazil., Edrada-Ebel R; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. |
| Abstrakt: |
Terminalia catappa L. (Combretaceae) is a medicinal plant that is part of the Brazilian biodiversity; this plant is popularly used for the treatment of a wide range of diseases. To better understand the chemical composition of T. catappa in different seasons, we conducted a thorough study using LC-MS and NMR data analysis techniques. The study helped obtain a chemical profile of the plant ethanolic extracts in different seasons of the year (spring, summer, autumn, and winter). The dereplication of LC-HRMS data allowed the annotation of 90 compounds in the extracts of T. catappa (hydrolyzable tannins, ellagic acid derivatives, and glycosylated flavonoids). Triterpenes and C -glycosyl flavones were the compounds that significantly contributed to differences observed between T. catappa plant samples harvested in autumn/winter and spring, respectively. The variations observed in the compound composition of the plant leaves may be related to processes induced by environmental stress and leaf development. Data fusion applied in the metabolomic profiling study allowed us to identify metabolites with greater confidence, and provided a better understanding regarding the production of specialized metabolites in T. catappa leaves under different environmental conditions, which may be useful to establish appropriate quality criteria for the standardization of this medicinal plant. |
