| Autor: |
White BD; Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK., Townley HE; Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK.; Department of Women's and Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX1 3PJ, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Materials (Basel, Switzerland) [Materials (Basel)] 2023 Mar 21; Vol. 16 (6). Date of Electronic Publication: 2023 Mar 21. |
| DOI: |
10.3390/ma16062482 |
| Abstrakt: |
Radio waves are highly penetrating, non-ionizing, and cause minimal damage to surrounding tissues. Radio wave control of drug release has been achieved using a novel thermoresponsive copolymer bound to a superparamagnetic iron oxide nanoparticle (SPION) core. A NIPAM-acrylamide-methacrolein copolymer underwent a coil-to-globular structure phase change upon reaching a critical temperature above the human body temperature but below hyperthermic temperatures. The copolymer was covalently bound to SPIONs which increase in temperature upon exposure to radio waves. This effect could be controlled by varying input energies and frequencies. For controlled drug release, proteins were bound via aldehyde groups on the copolymer and amine groups on the protein. The radio wave-induced heating of the complex thereby released the drug-bearing proteins. The fine-tuning of the radio wave exposure allowed multiple cycles of protein-drug release. The fluorescent tagging of the complex by FITC was also achieved in situ, allowing the tagging of the complex. The localization of the complex could also be achieved in vitro under a permanent magnetic field. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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