| Autor: |
Zorina SA; Department of Neurology, 'St. Andrew' County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania.; Department of Neurology, General Medicine Faculty, 'Ovidius' University, 900470 Constanta, Romania., Jurja S; Department of Ophthalmology, 'St. Andrew' County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania.; Department of Ophthalmology, General Medicine Faculty, 'Ovidius' University, 900470 Constanta, Romania., Mehedinti M; Department of Morphological and Functional Science, University of Medicine and Pharmacy, 'Dunarea de Jos', 800017 Galati, Romania., Stoica AM; Department of Ophthalmology, 'St. Andrew' County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania.; Department of Ophthalmology, General Medicine Faculty, 'Ovidius' University, 900470 Constanta, Romania., Chita DS; Department of Neurology, Faculty of General Medicine and Pharmacy, 'Vasile Goldis' Western University of Arad, 310045 Arad, Romania., Floris SA; Department of Orthopedy and Traumatology, 'St. Andrew' County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Axelerad A; Department of Neurology, 'St. Andrew' County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania.; Department of Neurology, General Medicine Faculty, 'Ovidius' University, 900470 Constanta, Romania. |
| Abstrakt: |
Infections represent a possible risk factor for parkinsonism and Parkinson's disease (PD) based on information from epidemiology and fundamental science. The risk is unclear for the majority of agents. Moreover, the latency between infection and PD seems to be very varied and often lengthy. In this review, the evidence supporting the potential involvement of infectious microorganisms in the development of Parkinson's disease is examined. Consequently, it is crucial to determine the cause and give additional treatment accordingly. Infection is an intriguing suggestion regarding the cause of Parkinson's disease. These findings demonstrate that persistent infection with viral and bacterial microorganisms might be a cause of Parkinson's disease. As an initiating factor, infection may generate a spectrum of gut microbiota dysbiosis, engagement of glial tissues, neuroinflammation, and alpha-synuclein accumulation, all of which may trigger and worsen the onset in Parkinson's disease also contribute to its progression. Still uncertain is the primary etiology of PD with infection. The possible pathophysiology of PD infection remains a matter of debate. Furthermore, additional study is required to determine if PD patients develop the disease due to infectious microorganisms or solely since they are more sensitive to infectious causes. |
