| Autor: |
Vasichkina E; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Kofeynikova O; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Fetisova S; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Starshinova AY; Medical Department, Saint Petersburg State Pediatric Medical University, St. Petersburg 194100, Russia., Sheyanova E; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Vershinina T; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Ryzhkov A; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Skripnik A; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Alekseeva D; Almazov National Medical Research Centre, St. Petersburg 197341, Russia.; H.Turner National Medical Research Center for Children's Orthopedics and Trauma Surgery, St. Petersburg 196603, Russia., Nechaeva E; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Glushkova A; V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, St. Petersburg 192019, Russia., Kudlay D; Pharmacology Department, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow 119435, Russia.; SSC Immunology Institute, FMBA Russia, Moscow 115552, Russia., Pervunina T; Almazov National Medical Research Centre, St. Petersburg 197341, Russia., Starshinova A; Almazov National Medical Research Centre, St. Petersburg 197341, Russia. |
| Abstrakt: |
The question of COVID-19 and long-COVID-19 course in children remains unsolved. This infection in children, which is associated with COVID-19, can vary from asymptomatic to systemic damage of various systems. Multisystem inflammatory syndrome in children, associated with SARS-CoV-2 (MIS-C), is a serious condition in children and adolescents after experiencing COVID-19. Published data on MIS-C have indicated that the inflammation can be registered in the gastrointestinal tract (60-100%), as well as in cardiovascular (80%), nervous (29-58%), and respiratory (21-65%) systems. However, with the changing characteristics of SARS-CoV-2, the manifestations of COVID-19 and long-COVID-19 in children have also been changing. Currently, there is no clear understanding of the development of severe COVID-19 and MIS-C in children, especially after being exposed to patients with COVID-19. We presented two new clinical courses of multisystem inflammatory syndrome in children with severe multisystem damage after close contact to relatives with COVID-19 or long-COVID-19. Thus, high-risk children, who are positive for SARS-CoV-2 infection after contact with COVID-19 patients, should be clinically managed during the first few months. The identification of the disease complexity requires the involvement of neurologists, cardiologists, and other specialists. |
