Quantitative Complexity Theory (QCT) in Integrative Analysis of Cardiovascular Hemodynamic Response to Posture Change.

Autor: Krzesiński P; Departament of Cardiology and Internal Diseases, Military Institute of Medicine, 04-141 Warsaw, Poland., Marczyk J; Ontonix s.r.l., 22100 Como, Italy., Wolszczak B; Ontonix s.r.l., 22100 Como, Italy., Gielerak GG; Departament of Cardiology and Internal Diseases, Military Institute of Medicine, 04-141 Warsaw, Poland., Accardi F; Boston Scientific S.p.A., 20134 Milano, Italy.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2023 Feb 24; Vol. 13 (3). Date of Electronic Publication: 2023 Feb 24.
DOI: 10.3390/life13030632
Abstrakt: The explanation of physiological mechanisms involved in adaptation of the cardiovascular system to intrinsic and environmental demands is crucial for both basic science and clinical research. Computational algorithms integrating multivariable data that comprehensively depict complex mechanisms of cardiovascular reactivity are currently being intensively researched. Quantitative Complexity Theory (QCT) provides quantitative and holistic information on the state of multi-functional dynamic systems. The present paper aimed to describe the application of QCT in an integrative analysis of the cardiovascular hemodynamic response to posture change. Three subjects that underwent head-up tilt testing under beat-by-beat hemodynamic monitoring (impedance cardiography) were discussed in relation to the complexity trends calculated using QCT software. Complexity has been shown to be a sensitive marker of a cardiovascular hemodynamic response to orthostatic stress and vasodilator administration, and its increase has preceded changes in standard cardiovascular parameters. Complexity profiling has provided a detailed assessment of individual hemodynamic patterns of syncope. Different stimuli and complexity settings produce results of different clinical usability.
Databáze: MEDLINE
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