Programming Factors of Neonatal Intestinal Dysbiosis as a Cause of Disease.

Autor: Jovandaric MZ; Department of Neonatology, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Dugalic S; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Babic S; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Babovic IR; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Milicevic S; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Mihajlovic D; Faculty of Medicine, University of Pristina Temporarily Settled in Kosovska Mitrovica, 38220, Serbia., Culjic M; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Zivanovic T; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Trklja A; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Markovic B; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Plesinac V; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Jestrovic Z; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Medjo B; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Department Pediatrics and Neonatal Intensive Care, University Children's Hospital, 11000 Belgrade, Serbia., Raus M; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Department of Neonatology, University Children's Hospital, 11000 Belgrade, Serbia., Dugalic MG; Department of Gynecology and Obstetrics, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 17; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 17.
DOI: 10.3390/ijms24065723
Abstrakt: The intestinal microbiota consists of trillions of bacteria, viruses, and fungi that achieve a perfect symbiosis with the host. They perform immunological, metabolic, and endocrine functions in the body. The microbiota is formed intrauterine. Dysbiosis is a microbiome disorder characterized by an imbalance in the composition of the microbiota, as well as changes in their functional and metabolic activities. The causes of dysbiosis include improper nutrition in pregnant women, hormone therapy, the use of drugs, especially antibiotics, and a lack of exposure to the mother's vaginal microbiota during natural birth. Changes in the intestinal microbiota are increasingly being identified in various diseases, starting in the early neonatal period into the adult period. Conclusions: In recent years, it has become more and more obvious that the components of the intestinal microbiota are crucial for the proper development of the immune system, and its disruption leads to disease.
Databáze: MEDLINE
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