Work-Related Psychosocial Factors and Global Cognitive Function: Are Telomere Length and Low-Grade Inflammation Potential Mediators of This Association?

Autor:	Duchaine CS; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; VITAM, Centre de Recherche en santé Durable, Québec, QC G1S 4L8, Canada.; Institut sur le Vieillissement et la Participation Sociale des Aînés, Université Laval, Québec, QC G1S 4L8, Canada., Brisson C; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; VITAM, Centre de Recherche en santé Durable, Québec, QC G1S 4L8, Canada., Diorio C; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada., Talbot D; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada., Maunsell E; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada., Carmichael PH; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada., Giguère Y; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada., Gilbert-Ouimet M; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; Canada Research Chair in Sex and Gender in Occupational Health, Université du Québec à Rimouski, Campus de Lévis, Lévis, QC G6V 0A6, Canada., Trudel X; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; VITAM, Centre de Recherche en santé Durable, Québec, QC G1S 4L8, Canada., Ndjaboué R; School of Social Work, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada., Vézina M; Institut National de Santé Publique du Québec (INSPQ), Québec, QC G1V 5B3, Canada., Milot A; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada., Mâsse B; École de Santé Publique de l'Université de Montréal, Montréal, QC H3N 1X9, Canada., Dionne CE; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; VITAM, Centre de Recherche en santé Durable, Québec, QC G1S 4L8, Canada.; Institut sur le Vieillissement et la Participation Sociale des Aînés, Université Laval, Québec, QC G1S 4L8, Canada., Laurin D; Centre d'excellence sur le vieillissement de Québec (CEVQ), CIUSSS-Capitale Nationale, Québec, QC G1S 4L8, Canada.; Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1S 4L8, Canada.; VITAM, Centre de Recherche en santé Durable, Québec, QC G1S 4L8, Canada.; Institut sur le Vieillissement et la Participation Sociale des Aînés, Université Laval, Québec, QC G1S 4L8, Canada.; Faculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2023 Mar 10; Vol. 20 (6). Date of Electronic Publication: 2023 Mar 10.
DOI:	10.3390/ijerph20064929
Abstrakt:	The identification of modifiable factors that could maintain cognitive function is a public health priority. It is thought that some work-related psychosocial factors help developing cognitive reserve through high intellectual complexity. However, they also have well-known adverse health effects and are considered to be chronic psychosocial stressors. Indeed, these stressors could increase low-grade inflammation and promote oxidative stress associated with accelerated telomere shortening. Both low-grade inflammation and shorter telomeres have been associated with a cognitive decline. This study aimed to evaluate the total, direct, and indirect effects of work-related psychosocial factors on global cognitive function overall and by sex, through telomere length and an inflammatory index. A random sample of 2219 participants followed over 17 years was included in this study, with blood samples and data with cognitive function drawn from a longitudinal study of 9188 white-collar workers (51% female). Work-related psychosocial factors were evaluated according to the Demand-Control-Support and the Effort-Reward Imbalance (ERI) models. Global cognitive function was evaluated with the validated Montreal Cognitive Assessment (MoCA). Telomere length and inflammatory biomarkers were measured using standardised protocols. The direct and indirect effects were estimated using a novel mediation analysis method developed for multiple correlated mediators. Associations were observed between passive work or low job control, and shorter telomeres among females, and between low social support at work, ERI or iso-strain, and a higher inflammatory index among males. An association was observed with higher cognitive performance for longer telomeres, but not for the inflammatory index. Passive work overall, and low reward were associated with lower cognitive performance in males; whereas, high psychological demand in both males and females and high job strain in females were associated with a higher cognitive performance. However, none of these associations were mediated by telomere length or the inflammatory index. This study suggests that some work-related psychosocial factors could be associated with shorter telomeres and low-grade inflammation, but these associations do not explain the relationship between work-related psychosocial factors and global cognitive function. A better understanding of the biological pathways, by which these factors affect cognitive function, could guide future preventive strategies to maintain cognitive function and promote healthy aging.
Databáze:	MEDLINE
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