Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study.

Autor:	Nicoletti VG; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy., Fisicaro F; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy., Aguglia E; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Bella R; Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, 95123 Catania, Italy., Calcagno D; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy., Cantone M; Neurology Unit, Policlinico University Hospital 'G. Rodolico-San Marco', 95123 Catania, Italy., Concerto C; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Ferri R; Clinical Neurophysiology Research Unit, Oasi Research Institute-IRCCS, 94018 Troina, Italy., Mineo L; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Pennisi G; Clinical Neurophysiology Research Unit, Oasi Research Institute-IRCCS, 94018 Troina, Italy., Ricceri R; Stroke Unit, Neurology Unit, Department of Neuroscience, Ospedale Civile di Baggiovara, Azienda Ospedaliero-Universitaria di Modena, 41126 Modena, Italy., Rodolico A; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Saitta G; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Torrisi G; Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy., Lanza G; Clinical Neurophysiology Research Unit, Oasi Research Institute-IRCCS, 94018 Troina, Italy.; Department of Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy., Pennisi M; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Mar 21; Vol. 11 (3). Date of Electronic Publication: 2023 Mar 21.
DOI:	10.3390/biomedicines11030958
Abstrakt:	Background: Although the antidepressant potential of repetitive transcranial magnetic stimulation (rTMS), the pleiotropic effects in geriatric depression (GD) are poorly investigated. We tested rTMS on depression, cognitive performance, growth/neurotrophic factors, cerebral blood flow (CBF) to transcranial Doppler sonography (TCD), and motor-evoked potentials (MEPs) to TMS in GD. Methods: In this case series study, six drug-resistant subjects (median age 68.0 years) underwent MEPs at baseline and after 3 weeks of 10 Hz rTMS on the left dorsolateral prefrontal cortex. The percentage change of serum nerve growth factor, vascular endothelial growth factor, brain-derived growth factor, insulin-like growth factor-1, and angiogenin was obtained. Assessments were performed at baseline, and at the end of rTMS; psychocognitive tests were also repeated after 1, 3, and 6 months. Results: Chronic cerebrovascular disease was evident in five patients. No adverse/undesirable effect was reported. An improvement in mood was observed after rTMS but not at follow-up. Electrophysiological data to TMS remained unchanged, except for an increase in the right median MEP amplitude. TCD and neurotrophic/growth factors did not change. Conclusions: We were unable to detect a relevant impact of high-frequency rTMS on mood, cognition, cortical microcircuits, neurotrophic/growth factors, and CBF. Cerebrovascular disease and exposure to multiple pharmacological treatments might have contributed.
Databáze:	MEDLINE
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