| Autor: |
Shah MZUH; Endocrinology Unit, Department of Bioscience, Barkatullah University, Bhopal 462026, India., Shrivastava VK; Endocrinology Unit, Department of Bioscience, Barkatullah University, Bhopal 462026, India., Sofi S; Department of Bioresources, School of Biological Sciences, University of Kashmir Srinagar, Srinagar 190006, India., Jamous YF; Vaccine and Bioprocessing Centre, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia., Khan MF; Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 16278, Saudi Arabia., Alkholifi FK; Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 16278, Saudi Arabia., Ahmad W; Department of Pharmacy, Mohammad Al-Mana College for Medical Sciences, Damman 34222, Saudi Arabia., Mir MA; Department of Bioresources, School of Biological Sciences, University of Kashmir Srinagar, Srinagar 190006, India. |
| Abstrakt: |
Around the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6-20% of females. Our study's major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabolic problems brought on by letrozole-induced PCOS. Group I served as the control for 81 days; Group II was given Letrozole (LETZ) orally at a dose of 6 mg/kg bw for 21 days to induce PCOS; Group III was given LETZ (6 mg/kg) for 21 days, followed by treatment with CGA (50 mg/kg bw daily) for 60 days. The study indicated that LETZ-treated mice displayed symptoms of PCOS, such as dyslipidemia, hyperinsulinemia, elevated testosterone, increases in inflammatory markers and malonaldehyde, and a decline in antioxidants (Ar, lhr, fshr, and esr2) in the ovaries. These alterations were affected when the mice were given CGA and were associated with reduced levels of adiponectin. Adiponectin showed interactions with hub genes, namely MLX interacting protein like (MLXIPL), peroxisome proliferator-activated receptor gamma Coactivator 1- alpha (PPARGC1), peroxisome proliferator-activated receptor gamma (Pparg), and adiponectin receptor 1 (Adipor1). Lastly, the gene ontology of adiponectin revealed that adiponectin was highly involved in biological processes. The findings from our research suggest that adiponectin has direct impacts on metabolic and endocrine facets of PCOS. |
