Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study.

Autor: Sheikh-Ahmad M; Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Saiegh L; Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel.; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel., Shalata A; Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Bejar J; Department of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Kreizman-Shefer H; Department of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Sirhan MF; Department of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Matter I; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.; Department of Surgery, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Swaid F; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.; Department of Surgery, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Laniado M; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.; Department of Surgery, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Mubariki N; Division of Gastroenterology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Rainis T; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.; Division of Gastroenterology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Rosenblatt I; Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Yovanovich E; Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel., Agbarya A; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.; Department of Oncology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel.
Jazyk: angličtina
Zdroj: Biomedicines [Biomedicines] 2023 Mar 09; Vol. 11 (3). Date of Electronic Publication: 2023 Mar 09.
DOI: 10.3390/biomedicines11030828
Abstrakt: Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11-288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21-67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; p = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; p = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.
Databáze: MEDLINE
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