| Autor: |
Dattilo S; CNR-Istituto per i Polimeri, Compositi e Biomateriali, Via Paolo Gaifami 18, I-95126 Catania, Italy., Spitaleri F; MEDIVIS-Via Carnazza 34 C, I-95030 Catania, Italy., Aleo D; MEDIVIS-Via Carnazza 34 C, I-95030 Catania, Italy., Saita MG; MEDIVIS-Via Carnazza 34 C, I-95030 Catania, Italy., Patti A; CNR-Istituto di Chimica Biomolecolare, Via Paolo Gaifami 18, I-95126 Catania, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomolecules [Biomolecules] 2023 Mar 03; Vol. 13 (3). Date of Electronic Publication: 2023 Mar 03. |
| DOI: |
10.3390/biom13030474 |
| Abstrakt: |
The use of iodine as antiseptic poses some issues related to its low water solubility and high volatility. Stable solid iodine-containing formulations are highly advisable and currently limited to the povidone-iodine complex. In this study, complexes of molecular iodine with 2-hydroxypropyl α-, β- and γ-cyclodextrins were considered water-soluble iodophors and prepared in a solid state by using three different methods (liquid-assisted grinding, co-evaporation and sealed heating). The obtained solids were evaluated for their iodine content and stability over time in different conditions using a fully validated UV method. The assessment of the actual formation of an inclusion complex in a solid state was carried out by thermal analysis, and the presence of iodine was further confirmed by SEM/EDX and XPS analyses. High levels of iodine content (8.3-10.8%) were obtained with all the tested cyclodextrins, and some influence was exerted by the employed preparation method. Potential use as solid iodophors can be envisaged for these iodine complexes, among which those with 2-hydroxypropyl-α-cyclodextrin were found the most stable, regardless of the preparation technique. The three prepared cyclodextrin-iodine complexes proved effective as bactericides against S. epidermidis . |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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