Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein-Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation.

Autor: da Silva GA; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Atum ALB; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., de Matos LP; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Nasuk GR; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., de Jesus BC; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Gouveia TLF; Odontology Department, Ágora Faculty, Av. Sorrento, Campo Novo do Parecis 78360-000, MT, Brazil.; Biomedicine Department, Finaci Faculty, Rua São Joaquim, 352 Liberdade, São Paulo 01508-901, SP, Brazil., Baltatu OC; Center of Innovation, Technology and Education (CITE), Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, Sao Jose dos Campos 12247-016, SP, Brazil., Zamuner SR; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Silva Júnior JA; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil.
Jazyk: angličtina
Zdroj: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 21; Vol. 12 (3). Date of Electronic Publication: 2023 Feb 21.
DOI: 10.3390/antiox12030541
Abstrakt: Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hippocampus and heart of mice of both sexes. C57Bl/6 mice were exposed to alcohol during pregnancy at a concentration of 10% ( v / v ). On postnatal day 45 (PN45), mouse hippocampi and left ventricles (LV) were collected and processed for messenger RNA (mRNA) expression of components of the RAS and KKS. In PAE animals, more pronounced expression of AT1 and ACE mRNAs in males and a restored AT2 mRNA expression in females were observed in both tissues. In LV, increased AT2 , ACE2 , and B2 mRNA expressions were also observed in PAE females. Furthermore, high levels of H 2 O 2 were observed in males from the PAE group in both tissues. Taken together, our results suggest that modulation of the expression of these peptidergic systems in PAE females may make them less susceptible to the effects of alcohol.
Databáze: MEDLINE
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