Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Autor: Schijven D; Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands., Postema MC; Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Fukunaga M; Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki 444-8585, Japan., Matsumoto J; Department of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan., Miura K; Department of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan., de Zwarte SMC; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands., van Haren NEM; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Sophia Children's Hospital, Rotterdam 3015 CN, The Netherlands., Cahn W; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands., Hulshoff Pol HE; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands., Kahn RS; Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, New York, NY 10468., Ayesa-Arriola R; Department of Psychiatry, Instituto de Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, Santander 39008, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander 39011, Spain., Ortiz-García de la Foz V; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Department of Psychiatry, Marqués de Valdecilla University Hospital, Instituto de Investigación Sanitaria Valdecilla, School of Medicine, University of Cantabria, Santander 39011, Spain., Tordesillas-Gutierrez D; Department of Radiology, Instituto de Investigación Marqués de Valdecilla, Marqués de Valdecilla University Hospital, Santander 39011, Spain.; Advanced Computing and e-Science, Instituto de Física de Cantabria, Universidad de Cantabria - Consejo Superior de Investigaciones Científicas, Santander 39005, Spain., Vázquez-Bourgon J; Department of Psychiatry, Instituto de Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, Santander 39008, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain., Crespo-Facorro B; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Department of Psychiatry, School of Medicine, University of Sevilla, University Hospital Virgen del Rocío, Consejo Superior de Investigaciones Científicas - Instituto de Biomedicina de Sevilla, Sevilla 41013, Spain., Alnæs D; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.; Department of Psychology, University of Oslo, Oslo 0373, Norway.; Bjørknes College, Oslo 0456, Norway., Dahl A; Department of Psychology, University of Oslo, Oslo 0373, Norway., Westlye LT; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.; Department of Psychology, University of Oslo, Oslo 0373, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0372, Norway.; KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo 0450, Norway., Agartz I; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo 0373, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden., Andreassen OA; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0372, Norway., Jönsson EG; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden., Kochunov P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201., Bruggemann JM; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia.; Edith Collins Centre (Translational Research in Alcohol, Drugs & Toxicology), Sydney Local Health District, Sydney 2050, Australia.; Specialty of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia., Catts SV; School of Medicine, The University of Queensland, Brisbane 4006, Australia., Michie PT; School of Psychological Sciences, University of Newcastle, Newcastle 2308, Australia., Mowry BJ; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane 4076, Australia., Quidé Y; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia., Rasser PE; Centre for Brain and Mental Health Research, University of Newcastle, Newcastle 2308, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle 2308, Australia.; Hunter Medical Research Institute, Newcastle 2305, Australia., Schall U; Centre for Brain and Mental Health Research, University of Newcastle, Newcastle 2308, Australia., Scott RJ; School of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle 2308, Australia., Carr VJ; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia., Green MJ; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia., Henskens FA; School of Medicine and Public Health, University of Newcastle, Newcastle 2308, Australia.; PRC for Health Behaviour, Hunter Medical Research Institute, Newcastle 2305, Australia., Loughland CM; School of Medicine and Public Health, University of Newcastle, Newcastle 2308, Australia.; Hunter New England Mental Health Service, Newcastle 2305, Australia., Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne 3053, Australia., Weickert CS; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia.; Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY 13210., Weickert TW; School of Psychiatry, University of New South Wales, Sydney 2033, Australia.; Neuroscience Research Australia, Sydney 2031, Australia.; Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY 13210., de Haan L; Early Psychosis Department, Department of Psychiatry, Amsterdam UMC (location AMC), Amsterdam 1105 AZ, The Netherlands.; Arkin Institute for Mental Health, Amsterdam 1033 NN, The Netherlands., Brosch K; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Pfarr JK; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Ringwald KG; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Stein F; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Jansen A; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany.; Core-Facility Brainimaging, Faculty of Medicine, Philipps-Universität Marburg, Marburg 35032, Germany., Kircher TTJ; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Nenadić I; Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.; Center for Mind, Brain and Behavior, Marburg 35032, Germany., Krämer B; Department of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Heidelberg University, Heidelberg 69115, Germany., Gruber O; Department of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Heidelberg University, Heidelberg 69115, Germany., Satterthwaite TD; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Lifespan Brain Institute, University of Pennsylvania & Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Bustillo J; Department of Psychiatry and Neuroscience, University of New Mexico, Albuquerque, NM 87106., Mathalon DH; Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, CA 94143.; Mental Health Service, Veterans Affairs San Francisco Healthcare System, San Francisco, CA 94121., Preda A; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697., Calhoun VD; Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA 30303., Ford JM; San Francisco VA Medical Center, University of California, San Francisco, CA 94121., Potkin SG; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697.; Long Beach VA Health Care System, Long Beach, CA 90822., Chen J; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China., Tan Y; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China., Wang Z; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China., Xiang H; Chongqing University Three Gorges Hospital, Chongqing 404188, P.R. China., Fan F; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China., Bernardoni F; Division of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, Technische Universität Dresden, University Hospital C.G. Carus, Dresden 01307, Germany.; Department of Child and Adolescent Psychiatry, Eating Disorder Treatment and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden 01307, Germany., Ehrlich S; Division of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, Technische Universität Dresden, University Hospital C.G. Carus, Dresden 01307, Germany.; Department of Child and Adolescent Psychiatry, Eating Disorder Treatment and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden 01307, Germany., Fuentes-Claramonte P; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Mental Health Research Networking Center (Ciber del Área de Salud Mental), Madrid 28029, Spain., Garcia-Leon MA; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Mental Health Research Networking Center (Ciber del Área de Salud Mental), Madrid 28029, Spain., Guerrero-Pedraza A; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Benito Menni Complex Assistencial en Salut Mental, Barcelona 08830, Spain., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Mental Health Research Networking Center (Ciber del Área de Salud Mental), Madrid 28029, Spain., Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Mental Health Research Networking Center (Ciber del Área de Salud Mental), Madrid 28029, Spain., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Mental Health Research Networking Center (Ciber del Área de Salud Mental), Madrid 28029, Spain., Ciullo V; Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy., Piras F; Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy., Vecchio D; Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy., Banaj N; Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy., Spalletta G; Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030., Michielse S; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands., van Amelsvoort T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands., Dickie EW; Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada.; Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada., Voineskos AN; Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada.; Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada., Sim K; West Region, Institute of Mental Health, Singapore 539747, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Ciufolini S; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Dazzan P; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Murray RM; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Kim WS; Department of Psychiatry, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; Research Institute of Clinical Medicine, Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54896, Republic of Korea., Chung YC; Department of Psychiatry, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.; Research Institute of Clinical Medicine, Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju 54896, Republic of Korea., Andreou C; Department of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland.; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23562, Germany., Schmidt A; Department of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland., Borgwardt S; Department of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland.; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23562, Germany., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom., Whalley HC; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom., Lawrie SM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom., du Plessis S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.; Stellenbosch University Genomics of Brain Disorders Research Unit, South African Medical Research Council, Cape Town 7505, South Africa., Luckhoff HK; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa., Scheffler F; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town 7935, South Africa., Emsley R; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa., Grotegerd D; Institute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster 48149, Germany., Lencer R; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23562, Germany.; Institute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster 48149, Germany., Dannlowski U; Institute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster 48149, Germany., Edmond JT; Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303., Rootes-Murdy K; Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303., Stephen JM; The Mind Research Network, Albuquerque, NM 87106., Mayer AR; The Mind Research Network, Albuquerque, NM 87106., Antonucci LA; Department of Education, Psychology, Communication, University of Bari Aldo Moro, Bari 70121, Italy., Fazio L; Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy., Pergola G; Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy., Bertolino A; Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.; Psychiatry Unit, Bari University Hospital, Bari 70121, Italy., Díaz-Caneja CM; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.; Ciber del Área de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid 28009, Spain.; School of Medicine, Universidad Complutense, Madrid 28040, Spain., Janssen J; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.; Ciber del Área de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid 28009, Spain., Lois NG; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid 28009, Spain., Arango C; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.; Ciber del Área de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid 28009, Spain.; School of Medicine, Universidad Complutense, Madrid 28040, Spain., Tomyshev AS; Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow 115522, Russian Federation., Lebedeva I; Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow 115522, Russian Federation., Cervenka S; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden.; Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala 751 85, Sweden., Sellgren CM; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 65, Sweden., Georgiadis F; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland., Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.; Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Canada., Kaiser S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.; Department of Psychiatry, Division of Adult Psychiatry, Geneva University Hospitals, Geneva 1202, Switzerland., Hajek T; National Institute of Mental Health, Klecany 250 67, Czech Republic.; Department of Psychiatry, Dalhousie University, Halifax B3H 2E2, Canada., Skoch A; National Institute of Mental Health, Klecany 250 67, Czech Republic.; MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic., Spaniel F; National Institute of Mental Health, Klecany 250 67, Czech Republic., Kim M; Department of Neuropsychiatry, Seoul National University Hospital, Seoul 08826, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea., Kwak YB; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea., Oh S; Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea., Kwon JS; Department of Neuropsychiatry, Seoul National University Hospital, Seoul 08826, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea., James A; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom., Bakker G; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands., Knöchel C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany., Stäblein M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany., Oertel V; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany., Uhlmann A; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.; Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden 01187, Germany., Howells FM; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town 7935, South Africa., Stein DJ; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town 7935, South Africa.; SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town 7505, South Africa., Temmingh HS; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa., Diaz-Zuluaga AM; Department of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia., Pineda-Zapata JA; Department of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia., López-Jaramillo C; Department of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia., Homan S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.; Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich 8050, Switzerland., Ji E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland., Surbeck W; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland., Homan P; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY 11030.; Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, New York, NY 11004.; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, New York, NY 11549., Fisher SE; Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 HB, The Netherlands., Franke B; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 HB, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands., Glahn DC; Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06102., Gur RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Lifespan Brain Institute, University of Pennsylvania & Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Radiology, Perelman School of Medicine, Philadelphia, PA 19104.; Department of Neurology, Perelman School of Medicine, Philadelphia, PA 19104., Hashimoto R; Department of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan., Jahanshad N; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033., Luders E; School of Psychology, University of Auckland, Auckland 1010, New Zealand.; Department of Women's and Children's Health, Uppsala University, Uppsala 752 37, Sweden.; Laboratory of Neuro Imaging, School of Medicine, University of Southern California, Los Angeles, CA 90033., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033., Turner JA; Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA 30303., van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA 92697., Francks C; Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 HB, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 04; Vol. 120 (14), pp. e2213880120. Date of Electronic Publication: 2023 Mar 28.
DOI: 10.1073/pnas.2213880120
Abstrakt: Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Databáze: MEDLINE