Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.

Autor: Cooper PJ; Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador.; Institute of Infection and Immunity, St George's University of London, London, UK., Figueiredo CA; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., Rodriguez A; Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador., Dos Santos LM; Departamento de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil., Ribeiro-Silva RC; Escola de Nutrição, Universidade Federal da Bahia, Salvador, Brazil., Carneiro VL; Departamento de Ciências da Vida, Universidade do Estado da Bahia, Salvador, Brazil., Costa G; Center for Data Knowledge and Integration for Health (CIDACS), Fundação Oswaldo Cruz, Bahia, Salvador, Brazil.; Universidade Salvador (UNIFACS), Salvador, Bahia, Brazil., Magalhães T; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil., Dos Santos de Jesus T; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., Rios R; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., da Silva HBF; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., Costa R; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., Chico ME; Fundacion Ecuatoriana para la Investigacion en Salud (FEPIS), Esmeraldas, Ecuador., Vaca M; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.; Fundacion Ecuatoriana para la Investigacion en Salud (FEPIS), Esmeraldas, Ecuador., Alcantara-Neves N; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil., Rodrigues LC; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Cruz AA; Universidade Federal da Bahia and Fundação ProAR, Salvador, Brazil., Barreto ML; Center for Data Knowledge and Integration for Health (CIDACS), Fundação Oswaldo Cruz, Bahia, Salvador, Brazil.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.
Jazyk: angličtina
Zdroj: Clinical and translational allergy [Clin Transl Allergy] 2023 Mar; Vol. 13 (3), pp. e12232.
DOI: 10.1002/clt2.12232
Abstrakt: Asthma is an important health concern in Latin America (LA) where it is associated with variable prevalence and disease burden between countries. High prevalence and morbidity have been observed in some regions, particularly marginalized urban populations. Research over the past 10 years from LA has shown that childhood disease is primarily non-atopic. The attenuation of atopy may be explained by enhanced immune regulation induced by intense exposures to environmental factors such as childhood infections and poor environmental conditions of the urban poor. Non-atopic symptoms are associated with environmental and lifestyle factors including poor living conditions, respiratory infections, psychosocial stress, obesity, and a diet of highly processed foods. Ancestry (particularly African) and genetic factors increase asthma risk, and some of these factors may be specific to LA settings. Asthma in LA tends to be poorly controlled and depends on access to health care and medications. There is a need to improve management and access to medication through primary health care. Future research should consider the heterogeneity of asthma to identify relevant endotypes and underlying causes. The outcome of such research will need to focus on implementable strategies relevant to populations living in resource-poor settings where the disease burden is greatest.
(© 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.)
Databáze: MEDLINE
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