A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.

Autor: Herrspiegel C; St. Erik Eye Hospital, Eugeniavägen 12, 4078, Stockholm, 171 64, Sweden.; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden., Plastino F; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden., Lardner E; St. Erik Eye Hospital, Eugeniavägen 12, 4078, Stockholm, 171 64, Sweden., Seregard S; St. Erik Eye Hospital, Eugeniavägen 12, 4078, Stockholm, 171 64, Sweden.; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden., Williams PA; St. Erik Eye Hospital, Eugeniavägen 12, 4078, Stockholm, 171 64, Sweden.; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden., André H; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden., Stålhammar G; St. Erik Eye Hospital, Eugeniavägen 12, 4078, Stockholm, 171 64, Sweden. gustav.stalhammar@ki.se.; Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, Tomtebodavägen 18A, Stockholm, 171 77, Sweden. gustav.stalhammar@ki.se.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2023 Mar 27; Vol. 23 (1), pp. 277. Date of Electronic Publication: 2023 Mar 27.
DOI: 10.1186/s12885-023-10757-x
Abstrakt: Purpose: To develop a prognostic test based on a single blood sample obtained at the time of uveal melanoma diagnosis.
Methods: 83 patients diagnosed with posterior uveal melanoma between 1996 and 2000 were included. Peripheral serum samples were obtained at diagnosis and kept at -80 °C until this analysis. Protein profiling of 84 cancer-related proteins was used to screen for potential biomarkers and a prognostic test that stratifies patients into metastatic risk categories was developed (serUM-Px) in a training cohort and then tested in a validation cohort.
Results: Low serum leptin levels and high osteopontin levels were found to identify patients with poor prognosis and were therefore selected for inclusion in the final test. In the validation cohort, patient sex and American Joint Committee on Cancer stages were similarly distributed between the low, intermediate, and high metastatic risk categories. With increasing metastatic risk category, patients had shorter metastasis-free- and overall survival, as well as greater cumulative incidence of uveal melanoma-related mortality in competing risk analysis (P = 0.007, 0.018 and 0.029, respectively). In multivariate Cox regression, serUM-Px was an independent predictor of metastasis with tumor size and patient sex as covariates (hazard ratio 3.2, 95% CI 1.5-6.9).
Conclusions: A prognostic test based on a single peripheral venous blood sample at the time of uveal melanoma diagnosis stratifies patients into low, intermediate, and high metastatic risk categories. Prospective validation will facilitate its clinical utility.
(© 2023. The Author(s).)
Databáze: MEDLINE
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