Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England.

Autor: Nafilyan V; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK. vahe.nafilyan@ons.gov.uk.; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK. vahe.nafilyan@ons.gov.uk., Bermingham CR; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK. charlotte.bermingham@ons.gov.uk., Ward IL; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK., Morgan J; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK., Zaccardi F; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK., Khunti K; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK., Stanborough J; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK., Banerjee A; Institute of Health Informatics, University College London, London, NW1 2DA, UK., Doidge JC; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.; Intensive Care National Audit and Research Centre, London, UK.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Mar 27; Vol. 14 (1), pp. 1541. Date of Electronic Publication: 2023 Mar 27.
DOI: 10.1038/s41467-023-36494-0
Abstrakt: Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.
(© 2023. Crown.)
Databáze: MEDLINE
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