Associations of Adolescent Alcohol Use and Self-Reported Alcohol Tolerance With Risk of Self-Harm and Suicide in Early Adulthood: A Birth-Cohort Study.

Autor:	Levola J; Department of Psychiatry, University of Helsinki, Helsinki, Finland.; Psychiatry, Hospital District of Helsinki and Uusimaa, Finland., Denisoff A; Department of Psychiatry, University of Turku, Turku, Finland., Mustonen A; Centre for Life Course Research, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Psychiatry, Seinäjoki Central Hospital, Finland., Alakokkare AE; Centre for Life Course Research, University of Oulu, Oulu, Finland., Miettunen J; Centre for Life Course Research, University of Oulu, Oulu, Finland., Bramness JG; Norwegian Institute of Public Health, Oslo, Norway.; The Arctic University of Norway, Tromsø, Norway.; Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Hamar, Norway., Niemelä S; Department of Psychiatry, University of Turku, Turku, Finland.; Addiction Psychiatry Unit, Department of Psychiatry, Turku University Hospital, Turku, Finland.
Jazyk:	angličtina
Zdroj:	Journal of studies on alcohol and drugs [J Stud Alcohol Drugs] 2023 Mar; Vol. 84 (2), pp. 198-207. Date of Electronic Publication: 2022 Nov 17.
DOI:	10.15288/jsad.22-00055
Abstrakt:	Objective: We aimed to assess the predictive associations of age at first drink (AFD), age at first intoxication (AFI), frequency of intoxication, and self-reported alcohol tolerance at ages 15-16 with self-harm requiring medical attention or suicide death by age 33. Method: In an ongoing follow-up study, the Northern Finland Birth Cohort 1986, a total of 7,735 individuals were included at ages 15-16. Information on alcohol and other substance use was assessed via questionnaires. Information on self-harm or suicide was collected from national registers until the participants were 33 years of age. Baseline psychiatric symptomatology measured with the Youth Self-Report questionnaire and sociodemographic background variables were controlled for in multivariable analyses using Cox regression analyses. Results: Male gender and psychiatric symptoms at ages 15-16 were consistently associated with greater risk of self-harm and suicide death. When baseline psychiatric symptomatology and other background variables were adjusted for, younger AFI (hazard ratio [HR] = 2.28, 95% CI [1.16, 4.47]) and high inherent alcohol tolerance (HR = 3.76, 95% CI [1.55, 9.08]) were associated with self-harm. Furthermore, frequent alcohol intoxication (HR = 5.39, 95% CI [1.44, 20.23]) and high inherent alcohol tolerance (HR = 6.20, 95% CI [1.18, 32.45]) were associated with suicide death by age 33. Conclusions: High alcohol tolerance, age at onset of intoxication, and frequency of alcohol intoxication in adolescence appear to be significant predictors of self-harm and suicide in early adulthood. Self-reported alcohol tolerance in adolescence is a novel empirical approach to assess adolescent alcohol use associating with subsequent harms.
Databáze:	MEDLINE
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