Sex differences in Parkinson disease-associated episodic memory and processing speed deficits.

Autor:	Reekes TH; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA.; LSU Health Shreveport Center for Brain Health, Shreveport, LA, USA., Higginson CI; Department of Psychology, Loyola University Maryland, Baltimore, MD, USA., Sigvardt KA; Department of Neurology, University of California Davis, Davis, CA, USA., King DS; Clinical Functional Neuroscience Department, Kaiser Permanente Northern California, Sacramento, CA, USA., Levine D; Clinical Functional Neuroscience Department, Kaiser Permanente Northern California, Sacramento, CA, USA., Wheelock VL; Department of Neurology, University of California Davis, Davis, CA, USA.; Clinical Functional Neuroscience Department, Kaiser Permanente Northern California, Sacramento, CA, USA., Disbrow EA; Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA.; LSU Health Shreveport Center for Brain Health, Shreveport, LA, USA.; Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Nov; Vol. 29 (9), pp. 813-820. Date of Electronic Publication: 2023 Mar 27.
DOI:	10.1017/S1355617723000097
Abstrakt:	Objectives: This study aims to address a gap in the data on cognitive sex differences in persons living with Parkinson disease (PD). There is some evidence that cognitive dysfunction is more severe in male PD, however data on episodic memory and processing speed is incomplete. Methods: One hundred and sixty-seven individuals with a diagnosis of PD were included in this study. Fifty-six of those individuals identified as female. The California Verbal Learning Test 1st edition and the Wechsler Memory Scale 3rd edition were used to evaluate verbal and visuospatial episodic memory and the Wechsler Adult Intelligence Scale 3rd edition was used to evaluate processing speed. Multivariate analysis of covariance was used to identify sex-specific differences across groups. Results: Our results show that males with PD performed significantly worse than females in verbal and visuospatial recall as well as a trend for the processing speed task of coding. Conclusions: Our finding of superior performance among females with PD in verbal episodic memory is consistent with reports in both healthy and PD individuals; however, females outperforming males in measures of visuospatial episodic memory is unique to PD. Cognitive deficits preferentially affecting males appear to be associated with frontal lobe-related function. Therefore, males may represent a disease subgroup more susceptible to disease mechanisms affecting frontal lobe deterioration and cognitive disturbances in PD.
Databáze:	MEDLINE
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