Temperature Control After Cardiac Arrest: A Narrative Review.

Autor: Fernandez Hernandez S; Department of Neurology, Baylor College of Medicine, 7200 Cambridge St Suite 9A, Houston, TX, 77030, USA. sh15@bcm.edu., Barlow B; Department of Pharmacy, Memorial Hermann the Woodlands Medical Center, The Woodlands, TX, USA., Pertsovskaya V; The George Washington University School of Medicine and Health Sciences, Washington, DC, 20037, USA., Maciel CB; Department of Neurology, University of Florida College of Medicine, Gainesville, FL, 32611, USA.; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, 32611, USA.; Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neurology, University of Utah, Salt Lake City, UT, 84132, USA.
Jazyk: angličtina
Zdroj: Advances in therapy [Adv Ther] 2023 May; Vol. 40 (5), pp. 2097-2115. Date of Electronic Publication: 2023 Mar 25.
DOI: 10.1007/s12325-023-02494-1
Abstrakt: Cardiac arrest (CA) is a critical public health issue affecting more than half a million Americans annually. The main determinant of outcome post-CA is hypoxic-ischemic brain injury (HIBI), and temperature control is currently the only evidence-based, guideline-recommended intervention targeting secondary brain injury. Temperature control is a key component of a post-CA care bundle; however, conflicting evidence challenges its wide implementation across the vastly heterogeneous population of CA survivors. Here, we critically appraise the available literature on temperature control in HIBI, detail how the evidence has been integrated into clinical practice, and highlight the complications associated with its use and the timing of neuroprognostication after CA. Future clinical trials evaluating different temperature targets, rates of rewarming, duration of cooling, and identifying which patient phenotype benefits from different temperature control methods are needed to address these prevailing knowledge gaps.
(© 2023. The Author(s).)
Databáze: MEDLINE